PMID: 9449236Feb 4, 1998Paper

Differential time course of induction of 1alpha,25-dihydroxyvitamin D3-24-hydroxylase mRNA expression in rats by 1alpha,25-dihydroxyvitamin D3 and its analogs

Life Sciences
T FuruichiY Ohyama

Abstract

In order to investigate the in vivo mechanisms of target gene activation by vitamin D3 analogs, we compared the effects of two vitamin D3 analogs, 22-oxa-1alpha,25-(OH)2D3 (OCT) and 2beta (3-hydroxypropoxy) -1alpha,25-(OH)2D3 (ED-71) with that of 1alpha,25-(OH)2D3 on 1alpha,25-(OH)2D3 -24-hydroxylase[24(OH)ase] mRNA expression in the kidney and intestine of normal rats. In these experiments, all three compounds induced 24(OH)ase mRNA, but the time course of induction for each respective treatment was clearly different. OCT caused the most rapid onset of increased 24(OH)ase mRNA expression and its subsequent return to pre-injection levels. In marked contrast, ED-71 was the slowest to increase expression which was prolonged over that observed with the other compounds tested. These differences probably relate to the pharmacokinetic properties of these analogs, which are mainly generated by the affinity of analogs for the vitamin D-binding protein(DBP).

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Citations

May 13, 2006·The Journal of Clinical Investigation·Changcheng ZhouKenneth E Thummel
Oct 4, 2012·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Misaki HiroseShigeru Kohno
Dec 18, 2003·Clinical and Experimental Pharmacology & Physiology·Vincenzo PanichiLuca Giovannini
Mar 13, 2013·Expert Opinion on Pharmacotherapy·Hiroshi Hagino
Apr 9, 2015·Canadian Journal of Physiology and Pharmacology·Hiroshi Hagino
May 5, 2001·The American Journal of Pathology·K MakibayashiT Doi
Dec 27, 2016·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Hideo SaitoEiji Itoi
Dec 23, 2011·American Journal of Nephrology·Aida LydiaYasuhiko Tomino

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