Differential time course of induction of rat liver microsomal cytochrome P-450 isozymes and epoxide hydrolase by Aroclor 1254

Archives of Biochemistry and Biophysics
A ParkinsonW Levin

Abstract

The time course of induction of rat liver microsomal cytochromes P-450a, P-450b + P-450e, P-450c, and P-450d and epoxide hydrolase has been determined in immature male rats administered a single large dose [1500 mumol (500 mg)/kg body wt] of the polychlorinated biphenyl mixture Aroclor 1254. Differential regulation of these xenobiotic-metabolizing enzymes was indicated by their characteristic patterns of induction. The rate of induction of cytochrome P-450a and epoxide hydrolase was relatively slow, and steady-state levels of these enzymes were maintained from approximately Days 9 to 15 after Aroclor 1254 treatment. In contrast, cytochrome P-450c was maximally induced 2 days after Aroclor 1254 treatment and remained at a constant level through Day 15. Steady-state levels of cytochrome P-450d, beginning 1 week after Aroclor 1254 treatment, were preceded by a fairly rapid rate of induction and possibly by a small decline from maximal levels observed around Days 4 to 5. Like those of the other cytochrome P-450 isozymes and epoxide hydrolase, the levels of cytochromes P-450b + P-450e were constant from Day 9 to 15 after Aroclor 1254 treatment. However, an unexpected but reproducible decline (approximately 25%) in total cytochrome P...Continue Reading

References

Jan 1, 1979·Pharmacology & Therapeutics·F P Guengerich
May 1, 1976·Journal of Toxicology and Environmental Health·R C BraunbergA M Blaschka
May 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·A P AlvaresA Kappas
Mar 1, 1974·Bulletin of Environmental Contamination and Toxicology·C L Litterst, E J van Loon
May 1, 1971·Bulletin of Environmental Contamination and Toxicology·O HutzingerV Zitko
Feb 16, 1972·Biochemical and Biophysical Research Communications·A Y Lu, W Levin
Mar 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·P M YuanJ E Shively
Jun 1, 1980·Chemico-biological Interactions·A ParkinsonS Safe
Mar 1, 1982·Archives of Biochemistry and Biophysics·G P Vlasuk, F G Walz
Nov 1, 1982·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·D E RyanW Levin

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Citations

May 2, 2000·Journal of Biochemical and Molecular Toxicology·E LeCluyseA Parkinson
Jan 1, 1990·Pharmacology & Therapeutics·D E Ryan, W Levin
Aug 17, 1994·Biochimica Et Biophysica Acta·D J SequeiraW L Backes
Jan 1, 1986·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·R BatelR K Zahn
Apr 1, 1995·Toxicology in Vitro : an International Journal Published in Association with BIBRA·L A VanaertsJ Noordhoek
Jul 14, 1998·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·P D DwivediS K Khanna
Jan 9, 1998·Drug Metabolism Reviews·P Honkakoski, M Negishi
May 1, 1994·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·K L SalyersI G Sipes
Jan 1, 1986·CRC Critical Reviews in Biochemistry·M Adesnik, M Atchison
May 15, 1987·Archives of Biochemistry and Biophysics·A J SonderfanA Parkinson
Aug 15, 1985·Archives of Biochemistry and Biophysics·N T NashedD M Jerina
Jan 1, 1990·Journal of Biochemical Toxicology·L van BreeJ de Vries
Jan 1, 1984·Annals of the New York Academy of Sciences·D E RyanW Levin
Jul 1, 1993·Toxicology and Industrial Health·G LucierJ Huff
Apr 7, 1997·Biochemical and Biophysical Research Communications·M J SantostefanoL S Birnbaum
Jun 30, 1986·Toxicology and Applied Pharmacology·P N Shaw, J B Houston
Jun 1, 1989·Archives of Biochemistry and Biophysics·C HassettC J Omiecinski
Sep 1, 1990·Archives of Biochemistry and Biophysics·P R SinclairJ F Sinclair

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