Differential tissue growth and cell adhesion alone drive early tooth morphogenesis: An ex vivo and in silico study

PLoS Computational Biology
Miquel Marin-RieraIsaac Salazar-Ciudad

Abstract

From gastrulation to late organogenesis animal development involves many genetic and bio-mechanical interactions between epithelial and mesenchymal tissues. Ectodermal organs, such as hairs, feathers and teeth are well studied examples of organs whose development is based on epithelial-mesenchymal interactions. These develop from a similar primordium through an epithelial folding and its interaction with the mesenchyme. Despite extensive knowledge on the molecular pathways involved, little is known about the role of bio-mechanical processes in the morphogenesis of these organs. We propose a simple computational model for the biomechanics of one such organ, the tooth, and contrast its predictions against cell-tracking experiments, mechanical relaxation experiments and the observed tooth shape changes over developmental time. We found that two biomechanical processes, differential tissue growth and differential cell adhesion, were enough, in the model, for the development of the 3D morphology of the early tooth germ. This was largely determined by the length and direction of growth of the cervical loops, lateral folds of the enamel epithelium. The formation of these cervical loops was found to require accelerated epithelial growt...Continue Reading

References

Feb 1, 1992·Trends in Genetics : TIG·M H Hardy
Feb 1, 1996·Developmental Dynamics : an Official Publication of the American Association of Anatomists·K SalmivirtaP Ekblom
Mar 12, 2010·Nature·Isaac Salazar-Ciudad, Jukka Jernvall
Mar 25, 2011·Molecular Ecology Resources·Christian Peter Klingenberg

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Citations

Aug 9, 2019·Journal of Dental Research·S YamadaJ B A Green
Oct 20, 2019·Development·Pascal F HagolaniIsaac Salazar-Ciudad
Aug 9, 2020·Frontiers in Physiology·Isabel Mogollón, Laura Ahtiainen
Jan 26, 2020·Development·Tingsheng Yu, Ophir D Klein
Feb 7, 2021·International Journal of Oral Science·Wei DuJimmy K Hu
Feb 25, 2021·PLoS Computational Biology·Pascal F HagolaniIsaac Salazar-Ciudad
May 28, 2021·The Journal of Cell Biology·Ewelina TrelaMarja L Mikkola
Jun 5, 2021·Proceedings of the National Academy of Sciences of the United States of America·Aidan M C CouzensMartin Rücklin

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Methods Mentioned

BETA
PCA

Software Mentioned

EmbryoMaker
MorphoJ
Procrustes
ImageJ
tpsDig

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