Differential toxin profiles of ciguatoxins in marine organisms: Chemistry, fate and global distribution

Toxicon : Official Journal of the International Society on Toxinology
Lucía Soliño, Pedro Reis Costa

Abstract

Ciguatoxins (CTXs) are fish metabolism products and a result of biotransformation of precursor gambiertoxins produced, in the first instance, by benthic dinoflagellates Gambierdiscus and Fukuyoa. Ciguatoxins are potent neurotoxins that selectively open voltage gated sodium channels in excitable cells causing the human food poisoning known as Ciguatera (CFP). Endemic from tropical areas in central Pacific and West Indian Ocean, and the Caribbean Sea, CTX may affect up to 500,000 people annually due to fish consumption. Their recent occurrence in European waters highlights the need for a multidisciplinary approach of CTX research in order to better understand the diversity and transformation of microalgae products through food webs. This article intends to review available information on chemistry, toxicity, distribution and fate of known CTX compounds from a critical perspective to provide an overview of future trends and needs on ciguatera research.

Citations

Dec 15, 2019·Toxins·Lisbet Díaz-AsencioMarie-Yasmine Dechraoui Bottein
Dec 2, 2020·Toxins·J Stephen Clark, Michael Popadynec
Jan 23, 2021·Animals : an Open Access Journal From MDPI·Andres Sanchez-HenaoFernando Real
Mar 6, 2021·The Journal of Organic Chemistry·Makoto SasakiKeisuke Arai
Jun 15, 2020·Biochemical Pharmacology·Volker HerzigGlenn F King
Apr 4, 2021·International Journal of Environmental Research and Public Health·Christopher R LoefflerDorina Bodi
Jun 19, 2021·Environmental Science & Technology·Jing LiPaul K S Lam
Feb 12, 2020·Aquatic Toxicology·Andres Sanchez-HenaoFernando Real
Aug 27, 2021·Toxins·Isabel do Prado LeiteMarie-Yasmine Dechraoui Bottein

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