PMID: 8970974Dec 1, 1996Paper

Differential transactivation of the intercellular adhesion molecule 1 gene promoter by Tax1 and Tax2 of human T-cell leukemia viruses

Journal of Virology
Y TanakaO Yoshie

Abstract

Previously, we showed that surface expression of intercellular adhesion molecule 1 (ICAM-1) was strongly upregulated in T cells carrying proviral human T-cell leukemia virus type 1 (HTLV-1) and that the viral transactivator protein Tax1 was capable of inducing the ICAM-1 gene. To determine the responsive elements in the human ICAM-1 gene promoter, a reporter construct in which the 5'-flanking 4.4-kb region of the ICAM-1 gene was linked to the promoterless chloramphenicol acetyltransferase (CAT) gene was cotransfected with expression vectors for Tax1 and Tax2, both of which were separately confirmed to be potent transactivators of the HTLV-1 long terminal repeat (LTR). Tax1 strongly activated the ICAM-1 promoter in all the cell lines tested: three T-cell lines (Jurkat, MOLT-4, and CEM), one monocytoid cell line (U937), and HeLa. Unexpectedly, Tax2 activated the ICAM-1 promoter only in HeLa. By deletion and mutation analyses of the 1.3-kb 5'-flanking region, we found that Tax1 transactivated the ICAM-1 promoter mainly via a cyclic AMP-responsive element (CRE)-like site at -630 to -624 in the Jurkat T-cell line and via an NF-kappaB site at -185 to -177 and an SP-1 site at -59 to -54 in HeLa. On the other hand, Tax2 was totally ina...Continue Reading

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Citations

Jan 31, 2002·World Journal of Gastroenterology : WJG·J XuL L Qin
Aug 16, 2008·Hematology·Satomi UedaAkihisa Kanamaru
Apr 21, 2009·Uirusu·Osamu Yoshie
Jan 8, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kunio HieshimaOsamu Yoshie
Mar 23, 2012·Immunological Reviews·Jonathan K Chan, Warner C Greene
Mar 27, 2007·Nature Reviews. Cancer·Masao Matsuoka, Kuan-Teh Jeang
Jul 1, 2010·Viruses·Mohamed Nejmeddine, Charles R M Bangham
Aug 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Giovanna TosiRoberto S Accolla
Jan 13, 2005·Environmental and Molecular Mutagenesis·Michael L GatzaSusan J Marriott
Nov 18, 2000·AIDS Research and Human Retroviruses·R MahieuxJ N Brady
Dec 15, 2019·Pathogens·Stefania FochiMaria Grazia Romanelli
Nov 16, 2005·Retrovirology·Sébastien A ChevalierRenaud Mahieux
Mar 23, 2006·Retrovirology·Noreen SheehyWilliam Hall

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