PMID: 15329476Aug 27, 2004Paper

Differential transcriptional and translational regulations of calbindin-D9k by steroid hormones and their receptors in the uterus of immature mice

The Journal of Reproduction and Development
Beum-Soo AnEui-Bae Jeung

Abstract

Calbindin-D(9k) (CaBP-9k) is a cytosolic calcium binding protein mainly expressed in the duodenum, placenta and uterus, and intestinal CaBP-9k is regulated by 1, 25-dyhydroxyvitamin D3. However, despite the presence of vitamin D receptors, uterine CaBP-9k is not under the control of vitamin D, but seems to be regulated by sex steroids. This steroids-dependent regulation of CaBP-9k is not only limited to a tissue-specific manner but also extends to a species-specific manner. In this study, we examined the regulation of CaBP-9k gene at the transcriptional and translational levels, and also localized CaBP-9k protein in the uterus of immature mice. Treatment with progesterone (P4) resulted in the induction of CaBP-9k mRNA, and a co-treatment with estrogen (E2) plus P4 evoked a synergic effect on its mRNA level in this tissue. Interestingly, the translation of CaBP-9k protein was enhanced by E2, while no difference was observed at the transcriptional level. Not only P4 but also E2 itself induced an increase of CaBP-9k protein, and co-treatment with E2 and P4 showed a similar effect on its protein level in the uterus of immature mice. The CaBP-9k protein was localized in the glandular epithelium of stroma in the uterus of immature mi...Continue Reading

References

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Jun 14, 2002·Molecular and Cellular Endocrinology·Beum-Soo AnEui-Bae Jeung
Jul 11, 2002·The American Journal of Cardiology·Donald P McDonnellJohn D Norris
Jan 22, 2004·Molecular Reproduction and Development·So-Mi YunEui-Bae Jeung
Feb 18, 2004·The Journal of Reproduction and Development·Kyung-Chul Choi, Eui-Bae Jeung

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Citations

Nov 18, 2005·Reproductive Biology and Endocrinology : RB&E·Kyung-Chul ChoiEui-Bae Jeung
Aug 19, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Geun-Shik LeeEui-Bae Jeung
Feb 16, 2018·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jin Yong AnEui-Bae Jeung
Mar 22, 2007·American Journal of Physiology. Endocrinology and Metabolism·Geun-Shik Lee, Eui-Bae Jeung
May 3, 2012·Menopause : the Journal of the North American Menopause Society·Wen-Fang ChenMan-Sau Wong
May 20, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jorge M NaciffGeorge P Daston
Feb 9, 2020·International Journal of Molecular Sciences·Bo-Hui JeonEui-Bae Jeung
Jan 17, 2007·Archives of Biochemistry and Biophysics·Shirin AkhterHector F DeLuca

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