Differential transmission of type 1 diabetes from diabetic fathers and mothers to their offspring

Diabetes
Valma HarjutsaloJaakko Tuomilehto

Abstract

We studied the incidence of type 1 diabetes in the offspring of patients with childhood- and adolescent-onset type 1 diabetes and several risk factors predicting the risk. We defined the diabetes status in the offspring of all probands who were included in the nationwide register of Finnish type 1 diabetic patients diagnosed at the age of < or =17 years from 1965 to 1979. A total of 5,291 offspring at risk contributed 72,220 person-years of follow-up between 1970 and 2003. Of them, 259 offspring developed type 1 diabetes by the end of 2003, giving a cumulative incidence of 6.7% (95% CI 5.9-7.5) by the age of 20 years. The incidence of type 1 diabetes in the offspring between the years 1980 and 2003 was 35.3, 44.6, and 44.6 per 10,000 person-years for the age-groups 0-4, 5-9, and 10-14 years, respectively. Poisson regression analyses showed a marked increase in incidence of 5.3% per year from 1983 to 2003. The greatest increase occurred in the youngest offspring, aged 0-4 years. Of the offspring of male probands, 7.8% were affected by the age of 20 years compared with 5.3% of the offspring of female probands (relative risk 1.7 [95% CI 1.3-2.2]). The young age at onset of diabetes increased the risk of type 1 diabetes in the offs...Continue Reading

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Citations

May 10, 2013·Diabetologia·L C Stene, E A M Gale
Sep 28, 2013·Current Diabetes Reports·Jaakko Tuomilehto
May 8, 2013·Trends in Endocrinology and Metabolism : TEM·Scott A Soleimanpour, Doris A Stoffers
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May 16, 2014·Canadian Journal of Diabetes·Jean-Marie EkoéRonald Goldenberg
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Jan 23, 2018·Diabetologia·Ute Schaefer-GrafUNKNOWN Diabetic Pregnancy Study Group
Jan 16, 2020·World Journal of Diabetes·Adebola Matthew GiwaAbdel Rahim A Hamad
Dec 31, 2020·International Journal of Molecular Sciences·Duaa Ahmed ElhagSouhaila Al Khodor
Jun 25, 2021·Frontiers in Immunology·Anna TorunBeata Pyrzynska
Jul 25, 2021·International Journal of Molecular Sciences·Witold BauerAdam Krętowski
Oct 17, 2009·Diabetes·Valma HarjutsaloPer-Henrik Groop

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