PMID: 9445034Jan 28, 1998Paper

Differential tropism and chemokine receptor expression of human immunodeficiency virus type 1 in neonatal monocytes, monocyte-derived macrophages, and placental macrophages

Journal of Virology
W R FearA L Cunningham

Abstract

Laboratory-adapted (LA) macrophage-tropic (M-tropic) human immunodeficiency virus type 1 (HIV-1) isolates (e.g., HIV-1(Ba-L)) and low-passage primary (PR) isolates differed markedly in tropism for syngeneic neonatal monocytes, monocyte-derived macrophages (MDMs), and placental macrophages (PMs). Newly adherent neonatal monocytes and cultured PMs were highly refractory to infection with PR HIV-1 isolates yet were permissive for LA M-tropic isolates. Day 4 MDMs were also permissive for LA M-tropic isolates and additionally, were permissive for over half the PR isolates tested. Qualitative differences in PR HIV-1 infection of monocytes/MDMs could not be correlated with CD4 levels alone, and in all three cell types the block to PR HIV-1 strain replication preceded reverse transcription. Neonatal monocyte susceptibility to PR HIV-1 strains correlated with increasing CCR-5 expression during maturation. CCR-5 could not be detected on newly adherent (day 1) neonatal monocytes, in contrast to adult monocytes (H. Naif et al., J. Virol. 72:830-836, 1998), but was readily detectable after 4 to 7 days of culture. However, moderate CCR-5 mRNA levels were present in day 1 neonatal monocytes and remained constant during monocyte maturation. CC...Continue Reading

References

Feb 1, 1992·AIDS Research and Human Retroviruses·P InnocentiJ M Seigneurin
Apr 25, 1992·Lancet·UNKNOWN European Collaborative Study
Oct 1, 1992·The Journal of Clinical Investigation·J A MikovitsF W Ruscetti
Apr 1, 1992·The Journal of Clinical Investigation·H SchuitemakerF Miedema
Dec 1, 1991·The Journal of Experimental Medicine·J B WeinbergM H Malim
Jan 1, 1992·Journal of Neuropathology and Experimental Neurology·L R Sharer
May 1, 1991·The Journal of Infectious Diseases·S ChandwaniW Borkowsky
Jan 1, 1991·The Journal of Clinical Investigation·M J McElrathZ A Cohn
Apr 1, 1990·Virology·B J PottsM A Martin
Jan 24, 1985·Nature·L RatnerK Baumeister
May 18, 1989·Nature·S Kwok, R Higuchi
Feb 11, 1983·Journal of Immunological Methods·C B WilsonW M Weaver
Feb 1, 1994·AIDS Research and Human Retroviruses·P A KrogstadI S Chen
May 1, 1995·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·L M FrenkelR C Reichman
Sep 1, 1993·The Journal of Infectious Diseases·A M KessonA L Cunningham
Mar 1, 1994·The Journal of Infectious Diseases·L T SpencerS A Spector
Aug 1, 1994·The Journal of Infectious Diseases·C M WilfertL Epstein
Dec 1, 1993·AIDS Research and Human Retroviruses·A R SperdutoI S Chen

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Citations

Jul 20, 2001·AIDS Research and Human Retroviruses·F Salvatori, G Scarlatti
Nov 16, 2002·Proceedings of the National Academy of Sciences of the United States of America·Yea-Lih LinPierre Corbeau
Dec 16, 2003·American Journal of Reproductive Immunology : AJRI·Juan Maldonado-EstradaGérard Chaouat
May 4, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Philip J EllerySuzanne M Crowe
Dec 15, 2010·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Loyda M MeléndezDianedis Toro-Nieves
Oct 6, 2001·Blood·S G TurvilleA L Cunningham
Jan 17, 2002·Acta Microbiologica Et Immunologica Hungarica·C Casper, E M Fenyö
Dec 6, 2003·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Katherine KedzierskaSuzanne M Crowe
May 6, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Edana CassolGuido Poli
Oct 26, 2011·AIDS Research and Human Retroviruses·Cintia M CrudeliLuisa Sen
May 22, 2002·Journal of Virology·Leslie A Obert, Edward A Hoover
Aug 12, 2000·Redox Report : Communications in Free Radical Research·R S GrantV Kapoor
Jan 8, 2003·Reviews in Medical Virology·Katherine KedzierskaAnthony L Cunningham
Jul 27, 2006·Proceedings of the National Academy of Sciences of the United States of America·Vasudha SundaravaradanNafees Ahmad
Jun 3, 2020·American Journal of Reproductive Immunology : AJRI·Deng AoMing-Qing Li
Aug 29, 2000·Journal of Acquired Immune Deficiency Syndromes : JAIDS·J C Martín, J C Bandrés
Dec 4, 2004·AIDS·Corinne Capoulade-MétayIoannis Theodorou
Sep 10, 2003·Journal of Leukocyte Biology·Kurt Vermeire, Dominique Schols
Jan 1, 2010·Journal of Leukocyte Biology·K García-CrespoL M Meléndez
Apr 25, 2008·Current Protocols in Immunology·Suzanne CroweKatherine Kedzierska
Jan 18, 2021·Life Sciences·Sepideh MeidaninikjehReza Jafari
Jun 21, 2001·Clinical Immunology : the Official Journal of the Clinical Immunology Society·A KalinkovichZ Bentwich
Feb 13, 2001·Journal of Reproductive Immunology·G C DouglasR Nuccitelli
Apr 21, 2001·Placenta·G C Douglas, T L Thirkill
Oct 9, 1999·The American Journal of Pathology·S V WestmorelandA A Lackner

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