Differential utilization of Ras signaling pathways by macrophage colony-stimulating factor (CSF) and granulocyte-macrophage CSF receptors during macrophage differentiation.

Molecular and Cellular Biology
F GuidezC K Glass

Abstract

Granulocyte-macrophage colony-stimulating factor (GM-CSF) and macrophage colony-stimulating factor (M-CSF) independently stimulate the proliferation and differentiation of macrophages from bone marrow progenitor cells. Although the GM-CSF and M-CSF receptors are unrelated, both couple to Ras-dependent signal transduction pathways, suggesting that these pathways might account for common actions of GM-CSF and M-CSF on the expression of macrophage-specific genes. To test this hypothesis, we have investigated the mechanisms by which GM-CSF and M-CSF regulate the expression of the macrophage scavenger receptor A (SR-A) gene. We demonstrate that induction of the SR-A gene by M-CSF is dependent on AP-1 and cooperating Ets domain transcription factors that bind to sites in an M-CSF-dependent enhancer located 4.1 to 4.5 kb upstream of the transcriptional start site. In contrast, regulation by GM-CSF requires a separate enhancer located 4.5 to 4.8 kb upstream of the transcriptional start site that confers both immediate-early and sustained transcriptional responses. Results of a combination of DNA binding experiments and functional assays suggest that immediate transcriptional responses are mediated by DNA binding proteins that are const...Continue Reading

References

Oct 30, 1992·Cell·T Pawson, G D Gish
Sep 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·K S MoultonC K Glass
Jan 1, 1990·International Journal of Cell Cloning·C J Sherr
Jun 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·W Wiktor-JedrzejczakE R Stanley
Oct 19, 1995·Nature·J N Ihle
Jul 14, 1995·The Journal of Biological Chemistry·M Karin
Jun 6, 1995·Proceedings of the National Academy of Sciences of the United States of America·A HorvaiC K Glass
Jan 1, 1994·Journal of Cell Science. Supplement·M F Roussel
Aug 1, 1994·The Journal of Experimental Medicine·W J de VilliersS Gordon
May 1, 1994·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·Y GengG K Hansson
Nov 1, 1995·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·S Gordon
Sep 1, 1996·Molecular and Cellular Biology·Y ZhuA D D'Andrea
Feb 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·A E HorvaiC K Glass
Jun 1, 1997·Molecular and Cellular Biology·R JasterA D D'Andrea

❮ Previous
Next ❯

Citations

Oct 16, 2015·Journal of Translational Medicine·Eugenia BelcastroAlessandro Corti
Sep 17, 2005·Immunobiology·David P SesterMatthew J Sweet
Sep 7, 2002·The Journal of Biological Chemistry·John S WelchChristopher K Glass
Feb 17, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·M P de WintherM H Hofker
Jun 14, 2008·Nature Reviews. Immunology·John A Hamilton
Jan 2, 2009·Digestive Diseases and Sciences·Helieh S OzWillem J S de Villiers
Aug 1, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Katharine M IrvineMatthew J Sweet
Nov 14, 2019·Experimental Dermatology·Romaine StalderNicolo Costantino Brembilla
Feb 3, 2004·The Journal of Biological Chemistry·Dominique Sawka-VerhelleChristopher K Glass
Oct 27, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lachlan M MoldenhauerSarah A Robertson
Apr 1, 2011·Journal of Phycology·Flavia Vischi WinckBernd Mueller-Roeber
Aug 15, 2018·International Journal of Molecular Sciences·Tsukasa Nakamura, Hidetaka Ushigome
Mar 18, 2009·Journal of Proteome Research·Erika CodarinGianluca Tell
May 25, 2021·The Science of the Total Environment·Wei GuoJay Gan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.