Differentially delayed development in the hand-wrist skeletons of children with cystic fibrosis: Round versus tubular bones

American Journal of Human Biology : the Official Journal of the Human Biology Council
Michael C Mahaney

Abstract

From a sample of 50 cystic fibrosis patients in whom a previous study had demosntrated a lack of statistical interdependence between disease severity and significant TW2-20 bone age delays, hand-wrist radiographs for a preadolescent subsample of 30 (14 females and 16 males, 7.4 to 13.0 years of age) are reassessed using the TW2 method to (1) elucidate any significant differences in maturational delays exhibited by the carpals and the tubular bones (radius, ulna, and short bones [RUS]) of the hand-wrist complex and (2) assess the relationships between the clinically derived measure of pulmonary disease severity, anthropometric indices of nutritional status, and the bone age delays in these two regions. Female and male carpal bone age delays, pulmonary disease severity scores, and weight/height(2) differ significantly. However, both sexes exhibit significant mean TW2-carpal bone age delays, while mean TW2-RUS ages are either non-significantly delayed or advanced with respect to normative standards. Correlation and all-subsets multiple linear regression analyses reveal no significant interdependence or predictive relationships between clinically derived measures of pulmonary disease severity and anthropometric measures of nutritio...Continue Reading

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Citations

Jan 18, 2017·American Journal of Human Biology : the Official Journal of the Human Biology Council·Katinka UtczasEva B Bodzsar
Jan 1, 1994·Nutrition and Health·K Ghebremeskel, M A Crawford

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