Differentially expressed proteins in positive versus negative HNSCC lymph nodes

BMC Medical Genomics
Alessandra VidottoEloiza H Tajara

Abstract

Lymph node metastasis is one of the most important prognostic factors in head and neck squamous cell carcinomas (HNSCCs) and critical for delineating their treatment. However, clinical and histological criteria for the diagnosis of nodal status remain limited. In the present study, we aimed to characterize the proteomic profile of lymph node metastasis from HNSCC patients. In the present study, we used one- and two-dimensional electrophoresis and mass spectrometry analysis to characterize the proteomic profile of lymph node metastasis from HNSCC. Comparison of metastatic and non-metastatic lymph nodes showed 52 differentially expressed proteins associated with neoplastic development and progression. The results reinforced the idea that tumors from different anatomical subsites have dissimilar behaviors, which may be influenced by micro-environmental factor including the lymphatic network. The expression pattern of heat shock proteins and glycolytic enzymes also suggested an effect of the lymph node environment in controlling tumor growth or in metabolic reprogramming of the metastatic cell. Our study, for the first time, provided direct evidence of annexin A1 overexpression in lymph node metastasis of head and neck cancer, addi...Continue Reading

References

May 18, 1996·Lancet·M B Sporn
Dec 11, 1999·Nucleic Acids Research·M Kanehisa, S Goto
Dec 14, 1999·The American Journal of Pathology·S Al-HaddadP H Watson
Dec 26, 2001·Nucleic Acids Research·Ron EdgarAlex E Lash
Mar 21, 2002·Nature Reviews. Cancer·Adrian L Harris
Mar 6, 2003·Oral Oncology·Eric M GendenCrispian Scully
Apr 6, 2004·Surgical Oncology Clinics of North America·Robert L Witt
Jul 13, 2004·Seminars in Cancer Biology·Albert Zlotnik
Sep 8, 2004·Biochemical and Biophysical Research Communications·Jens RauchOlivier Gires
Mar 10, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Trevor M Penning
Mar 10, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Shin-ichi FukumotoHiroyuki Aburatani
Mar 24, 2005·Cancer Metastasis Reviews·József TímárMiklós Kásler
Oct 13, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Quynh-Thu LeAlbert C Koong
Dec 17, 2005·Cancer Research·Ian KropKornelia Polyak
Aug 15, 2006·Journal of Cancer Research and Clinical Oncology·Jung-Hee LeeJeong-Hwa Lee
Feb 3, 2007·Seminars in Oncology·Gregory Renner
Mar 7, 2007·International Journal of Cancer. Journal International Du Cancer·Rosana Silistino-SouzaSonia M Oliani
Apr 4, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Naz Chaudary, Richard P Hill
Apr 19, 2007·Nature Reviews. Genetics·Don X Nguyen, Joan Massagué
Sep 11, 2007·American Journal of Obstetrics and Gynecology·Tal Biron-ShentalYoel Sadovsky
Jun 10, 2008·Developmental Cell·Jing Yang, Robert A Weinberg
Nov 19, 2008·BMC Research Notes·Patricia SeverinoUNKNOWN Head and Neck Genome Project GENCAPO
Dec 17, 2008·Histopathology·V A F AlvesM A Zago
Jan 10, 2009·Nature Protocols·Da Wei HuangRichard A Lempicki
Jan 24, 2009·Acta histochemica·Susan A BrooksDebbie M S Hall
Mar 6, 2009·Nature Reviews. Cancer·Kornelia Polyak, Robert A Weinberg
Mar 13, 2009·Nature Reviews. Cancer·Johanna A Joyce, Jeffrey W Pollard
Mar 25, 2009·Laboratory Investigation; a Journal of Technical Methods and Pathology·Naz Chaudary, Richard P Hill
Dec 31, 2009·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Lei-Ya FangYuh-Ling Chen

❮ Previous
Next ❯

Citations

Jan 24, 2020·Frontiers in Oncology·Virgínea de Araújo FariasJosé Mariano Ruiz de Almodóvar
Sep 25, 2019·Journal of Medicinal Chemistry·Vincent FaganUdo Oppermann

❮ Previous
Next ❯

Methods Mentioned

BETA
electrophoresis
biopsies
bronchoalveolar lavage
dissection

Software Mentioned

Scaffold
MassLynx
ImageMaster 2D Platinum
AxioVision
Image J
Mascot Daemon
Proteome
Protein Atlas
Mascot
Mascot Distiller

Related Concepts

Related Feeds

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Related Papers

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics
Kenichi KumagaiRyuji Suzuki
Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
Lei TaoJean Lacau St Guily
© 2022 Meta ULC. All rights reserved