Differentiate to thrive: lessons from the Legionella pneumophila life cycle

Molecular Microbiology
Ari B Molofsky, Michele S Swanson

Abstract

When confronted by disparate environments, microbes routinely alter their physiology to tolerate or exploit local conditions. But some circumstances require more drastic remodelling of the bacterial cell, as sporulation by the Bacillus and Streptomyces species of soil bacteria vividly illustrates. Cellular differentiation is also crucial for pathogens, the challenge for which is to colonize one host, then be transmitted to the next. Using the Gram-negative Legionella pneumophila as a model intracellular pathogen, we describe how biogenesis of the replication vacuole is determined by the developmental state of the bacterium. Subsequently, when replicating bacteria have exhausted the nutrient supply, the pathogens couple their conversion to stationary phase physiology with expression of traits that promote transmission to a new host. The cellular differentiation of L. pneumophila is co-ordinated by a regulatory circuit that integrates several elements that are broadly conserved in the microbial world. The alarmone (p)ppGpp promotes transcription directed by the alternative sigma factors RpoS, FliA and, probably, RpoN, and also post-transcriptional control mediated by a two-component regulatory system, LetA/S (GacA/S), and an mRNA...Continue Reading

References

Jun 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·N P Cianciotto, B S Fields
Sep 1, 1995·Infection and Immunity·M S Swanson, R R Isberg
Jul 1, 1997·Journal of Bacteriology·M Y Liu, T Romeo
Jun 25, 1998·Infection and Immunity·B Byrne, M S Swanson
Oct 10, 1998·Molecular Microbiology·A FarewellT Nyström
Mar 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·C C Häse, J J Mekalanos
Aug 14, 1999·Molecular Microbiology·B K Hammer, M S Swanson
Oct 6, 2000·Annual Review of Microbiology·M S Swanson, B K Hammer
Nov 9, 2000·The Journal of Experimental Medicine·S Sturgill-Koszycki, M S Swanson
Dec 19, 2000·Infection and Immunity·S L CirilloJ D Cirillo
Apr 3, 2001·Current Opinion in Microbiology·D Chatterji, A K Ojha
Jan 5, 2002·Molecular Plant-microbe Interactions : MPMI·S Heeb, D Haas
Jan 16, 2002·Journal of Bacteriology·Clare M TaylorIan S Roberts
Mar 12, 2002·Traffic·Michele S SwansonEsteban Fernandez-Moreia
Mar 12, 2002·Traffic·Jessica A Sexton, Joseph P Vogel
Mar 28, 2002·Applied and Environmental Microbiology·Yumiko OkadaShouji Yamazaki
Apr 23, 2002·Molecular Microbiology·Brian K HammerMichele S Swanson
May 23, 2002·Genes & Development·Miki JishageThomas Nyström
Jun 22, 2002·FEMS Microbiology Letters·Hagen WielandBirgid Neumeister
Jul 5, 2002·Clinical Microbiology Reviews·Barry S FieldsRichard E Besser
Nov 8, 2002·The Journal of Biological Chemistry·Andrew D LaurieVictoria Shingler

❮ Previous
Next ❯

Citations

Oct 6, 2012·Molecular Plant-microbe Interactions : MPMI·Kasumi TakeuchiDieter Haas
Feb 7, 2018·Frontiers in Cellular and Infection Microbiology·Giulia OlivaCarmen Buchrieser
Dec 19, 2017·Frontiers in Cellular and Infection Microbiology·Amrita LamaEric D Cambronne
Feb 8, 2011·Applied and Environmental Microbiology·Andrew BryanMichele S Swanson
Jan 31, 2014·Infection and Immunity·Maris V FonsecaMichele S Swanson
Jan 16, 2013·Infection and Immunity·Rachel L EdwardsMichele S Swanson
Mar 13, 2016·Applied and Environmental Microbiology·Kelsi M SandozRobert A Heinzen
Sep 12, 2012·Infection and Immunity·Deepak JayakumarHoward M Steinman
Jan 9, 2015·Clinical Microbiology Reviews·Jeffrey W Mercante, Jonas M Winchell
Nov 25, 2014·Applied and Environmental Microbiology·Hana TriguiSebastien P Faucher
Feb 13, 2019·Journal of Bacteriology·Derek E MoormeierRobert A Heinzen
Jun 17, 2011·Nature Reviews. Microbiology·Klaus Aktories
Feb 18, 2012·Nature Reviews. Microbiology·Zachary D Dalebroux, Michele S Swanson
Jun 7, 2014·The Journal of Biological Chemistry·Eva SchunderKlaus Heuner
Jan 5, 2008·Microbiology·Derek E ChenMilton H Saier
Nov 3, 2007·Microbiology·Leen VranckxElke Lammertyn
Oct 29, 2019·Annual Review of Pathology·Sonia MondinoCarmen Buchrieser
Mar 4, 2020·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Abdelwahid AssaidiEl Mostafa Mliji
Jan 23, 2016·The Journal of Biological Chemistry·Nadine GillmaierKlaus Heuner
Apr 12, 2006·The Journal of Experimental Medicine·Ari B MolofskyMichele S Swanson
May 13, 2005·Cellular Microbiology·Amal O Amer, Michele S Swanson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Respiration

This feed focuses on cellular respiration in bacteria, known as bacterial respiration. Discover the latest research here.