Differentiated thyroid cancer with liver metastases: lessons learned from managing a series of 14 patients

International Surgery
C BrientA Hamy

Abstract

Liver metastases from differentiated thyroid carcinoma (LMDTC) are rare and usually occur in disseminated metastatic disease. The aim of this study was to review the diagnosis and management of LMDTC. Between 1995 and 2011, 14 patients with a mean age of 59.7 years (+/-10.2) were treated for LMDTC. Data were retrospectively reviewed and analyzed. Seven patients had distant metastases at diagnosis, including 2 with synchronous liver lesions. The average time of onset of LMDTC from initial diagnosis was 52.2 months (+/49.5). All LMDTC were discovered during routine radiologic monitoring. Histologic analysis confirmed LMDTC in 5 patients. Eight patients received tyrosine kinase inhibitors, 1 patient underwent resection of their LMDTC after chemotherapy. Six patients (disseminated metastases, significant comorbidities) did not receive any specific treatment. The median survival after diagnosis of LMDTC was 17.4 months (+/-3.3): 23.6 months (+/-2.9) for patients who underwent chemotherapy versus 3.9 months (+/-0.9) for patients who did not receive any specific treatment (P < 0.001). Developing DTC liver metastasis is a very poor prognostic sign. Chemotherapy by TKIs, especially, hold promise in the cure of LMDTC for selected patients.

References

Oct 19, 1978·The New England Journal of Medicine·J ScottT J Peters
Dec 1, 1996·Thyroid : Official Journal of the American Thyroid Association·D H Shah, A M Samuel
Mar 25, 1999·Thyroid : Official Journal of the American Thyroid Association·R GuglielmiE Papini
Apr 24, 1999·The Annals of Thoracic Surgery·P Fonseca
Dec 20, 2002·Thyroid : Official Journal of the American Thyroid Association·Andrew J BauerGary L Francis
Aug 26, 2004·JAMA : the Journal of the American Medical Association·Branavan SivakumarEwa M Paleolog
Jan 15, 2005·Otolaryngologic Clinics of North America·Richard O Wein, Randal S Weber
Mar 25, 2006·European Journal of Endocrinology·Ying Y LiuJohannes W A Smit
Sep 25, 2007·Arquivos brasileiros de endocrinologia e metabologia·Nathan C Hall, Richard T Kloos
Jun 11, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Vandana Gupta-AbramsonMarcia S Brose
Jun 11, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ezra E W CohenRoger B Cohen
Jul 4, 2008·The New England Journal of Medicine·Steven I ShermanUNKNOWN Motesanib Thyroid Cancer Study Group
Oct 15, 2008·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Raghu Vikram, Revathy B Iyer
Mar 4, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Richard T KloosManisha H Shah
Feb 15, 2013·The New England Journal of Medicine·Alan L HoJames A Fagin

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Citations

Jul 22, 2019·Endocrine·Anabela ZuninoUNKNOWN Thyroid Department of Sociedad Argentina de Endocrinología y Metabolismo
Jan 26, 2021·Clinical Nuclear Medicine·Bernadette Z Y WongDavid A Pattison
Aug 19, 2021·Thyroid : Official Journal of the American Thyroid Association·Viktoria Florentine KoehlerChristine Spitzweg

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