Differentiating Between Cancer and Inflammation: A Metabolic-Based Method for Functional Computed Tomography Imaging

ACS Nano
Menachem MotieiRachela Popovtzer

Abstract

One of the main limitations of the highly used cancer imaging technique, PET-CT, is its inability to distinguish between cancerous lesions and post treatment inflammatory conditions. The reason for this lack of specificity is that [(18)F]FDG-PET is based on increased glucose metabolic activity, which characterizes both cancerous tissues and inflammatory cells. To overcome this limitation, we developed a nanoparticle-based approach, utilizing glucose-functionalized gold nanoparticles (GF-GNPs) as a metabolically targeted CT contrast agent. Our approach demonstrates specific tumor targeting and has successfully distinguished between cancer and inflammatory processes in a combined tumor-inflammation mouse model, due to dissimilarities in angiogenesis occurring under different pathologic conditions. This study provides a set of capabilities in cancer detection, staging and follow-up, and can be applicable to a wide range of cancers that exhibit high metabolic activity.

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Citations

May 26, 2017·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Rinat Meir, Rachela Popovtzer
Dec 7, 2018·Journal of Materials Science. Materials in Medicine·Man TheerasilpNorased Nasongkla
Jun 17, 2020·Journal of Biophotonics·Eran A BarnoyDror Fixler
Jul 22, 2018·Nanomedicine·Tamar DreifussRachela Popovtzer
Nov 14, 2017·Head & Neck·Erez Shmuel DavidiRachela Popovtzer
Oct 17, 2017·Scientific Reports·Rimi LeeKyung-Hwa Yoo
Mar 28, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Tao ZhangZhigang Xie
May 10, 2017·Physiological Measurement·Richard BayfordScarlet Xiaoyan Wang
Jul 2, 2019·Biomedical Optics Express·Inbar YarivDror Fixler
Feb 10, 2021·Biomedicines·Meredith A JonesLacey R McNally
Jun 9, 2020·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Elise LepeltierCatherine Passirani
May 29, 2021·Radiology. Imaging Cancer·Christina H Liu, Piotr Grodzinski
Apr 11, 2018·ACS Central Science·Dokyoon KimTaeghwan Hyeon
Dec 29, 2020·ACS Nano·Chen Tzror-AzankotRachela Popovtzer
Sep 30, 2017·ACS Nano·Oshra BetzerRachela Popovtzer
Feb 20, 2018··Hamootal DuadiDror Fixler
Feb 20, 2018··Marc Jose Jonathan KindlerErez S. Davidi
May 6, 2020··Satya Pal SinghKrishna M. Rao

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