Differentiating Cerebellar Impact on Thalamic Nuclei

Cell Reports
Simona V GornatiFreek E Hoebeek

Abstract

The cerebellum plays a role in coordination of movements and non-motor functions. Cerebellar nuclei (CN) axons connect to various parts of the thalamo-cortical network, but detailed information on the characteristics of cerebello-thalamic connections is lacking. Here, we assessed the cerebellar input to the ventrolateral (VL), ventromedial (VM), and centrolateral (CL) thalamus. Confocal and electron microscopy showed an increased density and size of CN axon terminals in VL compared to VM or CL. Electrophysiological recordings in vitro revealed that optogenetic CN stimulation resulted in enhanced charge transfer and action potential firing in VL neurons compared to VM or CL neurons, despite that the paired-pulse ratio was not significantly different. Together, these findings indicate that the impact of CN input onto neurons of different thalamic nuclei varies substantially, which highlights the possibility that cerebellar output differentially controls various parts of the thalamo-cortical network.

Citations

Mar 4, 2019·The Cerebellum·Christophe HabasPierre Cabaraux
May 6, 2020·The FEBS Journal·Gen OhtsukiAkitoshi Ozaki
Jun 6, 2019·The Cerebellum·Lauren N MiterkoRoy V Sillitoe
Apr 9, 2020·International Journal of Molecular Sciences·Francesca PrestoriLisa Mapelli
Jul 8, 2019·Neurobiology of Disease·Anthony M DownsPaola Bonsi
Jan 26, 2021·The Journal of Physiology·Carmen B SchäferFreek E Hoebeek
Nov 19, 2020·Nature Reviews. Neuroscience·Chris I De Zeeuw
Nov 9, 2020·Progress in Neurobiology·W XuA Jackson
May 4, 2020·Neuroscience·Masaki TanakaRyuji Takeya
May 23, 2021·Brain Stimulation·Oscar H J Eelkman RoodaFreek E Hoebeek
Feb 10, 2020·Epilepsy & Behavior : E&B·Martha L Streng, Esther Krook-Magnuson
Jul 25, 2021·Current Biology : CB·Naoya TakahashiDieter Jaeger
Jul 14, 2021·Neuroscience Letters·Enes AkyuzLeonid S Godlevsky

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Methods Mentioned

BETA
confocal microscopy
transfect
transfection
dissection

Software Mentioned

Scientific Volume Imaging
SPSS
Fiji
ImageJ
- scripts
Huygens
Sholl

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