Differentiating epilepsy from psychogenic nonepileptic seizures using neuropsychological test data

Epilepsy & Behavior : E&B
Brad T TysonLaszlo A Erdodi

Abstract

Differentiating epileptic seizures (ES) from psychogenic nonepileptic seizures (PNES) represents a challenging differential diagnosis with important treatment implications. This study was designed to explore the utility of neuropsychological test scores in differentiating ES from PNES. Psychometric data from 72 patients with ES and 33 patients with PNES were compared on various tests of cognitive ability and performance validity. Individual measures that best discriminated the diagnoses were then entered as predictors in a logistic regression equation with group membership (ES vs. PNES) as the criterion. On most tests of cognitive ability, the PNES sample outperformed the ES sample (medium-large effect) and was less likely to fail the Reliable Digit Span. However, patients with PNES failed two embedded validity indicators at significantly higher rates (risk ratios (RR): 2.45-4.16). There were no group differences on the Test of Memory Malingering (TOMM). A logistic regression equation based on seven neuropsychological tests correctly classified 85.1% of patients. The cutoff with perfect specificity was associated with 0.47 sensitivity. Consistent with previous research, the utility of psychometric methods of differential diagno...Continue Reading

Citations

Feb 23, 2019·Journal of Clinical and Experimental Neuropsychology·Thomas BodnerThomas Benke
Nov 7, 2019·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Laszlo A Erdodi, Christopher A Abeare
Jul 15, 2020·The Clinical Neuropsychologist·Christopher A AbeareLaszlo A Erdodi
Jul 12, 2020·Journal of Neurology, Neurosurgery, and Psychiatry·Laura McWhirterAlan Carson
Dec 4, 2019·Applied Neuropsychology. Adult·Phillip OllaLaszlo A Erdodi
Feb 16, 2021·Epilepsy & Behavior : E&B·Cynthia CáceresJuan Luis Becerra
May 31, 2020·The Journal of Head Trauma Rehabilitation·Laszlo ErdodiChristopher Abeare
Mar 19, 2021·Epilepsy & Behavior : E&B·Ahmed RadyAya Radwan
Oct 15, 2020·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Laurence BinderSandy K Tadrous-Furnanz
Jun 14, 2021·Neuroscience and Biobehavioral Reviews·Ali A Asadi-PooyaGaston Baslet

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