Differentiating keratoacanthoma from squamous cell carcinoma by the use of apoptotic and cell adhesion markers

Michael Slater, Julian A Barden


Keratoacanthomas (KA) are well-differentiated squamoproliferative skin lesions that grow rapidly and regress spontaneously. In contrast, squamous cell carcinomas (SCC) can have variable differentiation, inexorably progress and on occasion metastasize. Distinguishing between KA and SCC using haematoxylin and eosin-stained sections from an initial biopsy can often be difficult. There is also some debate as to whether KA is simply a variety of well-differentiated SCC or a distinct entity. Initial biopsy sections from 25 cases of SCC and 20 of KA were labelled with markers for both the initiation (the cytolytic receptor P2X7) and end-stage (terminal deoxynucleotidyl transferase biotin-dUTP nick end labelling) of apoptosis, telomerase-associated protein (TP1) and the cell adhesion protein E-cadherin. As this was a retrospective study, the clinical outcome of each case was known. This resulted in a unique labelling pattern of each marker for SCC and KA, allowing a differential diagnosis between the two conditions. The simplest marker to use for this purpose was anti-P2X7. Sections from five cases that were initially very difficult to diagnose were correctly identified as SCC using this method. These results support the view that KA h...Continue Reading


Apr 1, 1994·Histopathology·K BlessingP M Gordon
Aug 1, 1993·The American Journal of Dermatopathology·E HodakA B Ackerman
May 9, 1998·Surgical and Radiologic Anatomy : SRA·L KornreichN Gadoth
May 26, 1998·Annals of Plastic Surgery·C H MansteinJ E Besden
Dec 11, 1999·Dermatology : International Journal for Clinical and Investigative Dermatology·B CribierE Grosshans
Jun 30, 2000·The Journal of Dermatology·S KosekiS Kondo
Aug 8, 2001·The Australasian Journal of Dermatology·A M GodboltD Weedon
Jan 18, 2002·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Perkins MukunyadziBruce R Smoller
Feb 13, 2003·The Journal of Pathology·Michael SlaterJulian A Barden
Apr 12, 2003·Melanoma Research·Michael SlaterJulian A Barden


Jun 3, 2009·Archives of Dermatological Research·Aikaterini MastorakiKiriaki Aroni
Feb 9, 2016·Journal of the American Academy of Dermatology·Bartlomiej Kwiek, Robert A Schwartz
Jun 15, 2010·Clinics in Dermatology·Christine J Ko
Dec 15, 2007·Pathology, Research and Practice·Daniel RibeiroMariângela E A Marques
Oct 24, 2007·Pathology, Research and Practice·Kiriaki AroniEleftherios Ioannidis
Aug 10, 2007·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Jörg HandschelAlfred Böcking
Jul 7, 2007·International Journal of Dermatology·Amel Karaa, Amor Khachemoune
Jan 24, 2009·International Journal of Cancer. Journal International Du Cancer·Natasa VasiljevićOla Forslund
Mar 18, 2011·Experimental Dermatology·Angelos SkyrlasIoannis D Bassukas
Dec 10, 2014·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Vivian Petersen WagnerCristiane Helena Squarize
Feb 14, 2015·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Seong H RaScott W Binder
May 16, 2009·International Journal of Surgical Pathology·Aikaterini MastorakiKiriaki Aroni
Oct 16, 2019·Indian Journal of Pathology & Microbiology·Gulay TuranOzgur Kulahci
Jun 26, 2020·Frontiers in Pharmacology·Romain LaraShaun McNulty
Nov 29, 2013·International Journal of Surgical Pathology·Phyu P AungMeera Mahalingam

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