Differentiating tic electrophysiology from voluntary movement in the human thalamocortical circuit

Journal of Neurology, Neurosurgery, and Psychiatry
Jackson N CagleAysegul Gunduz

Abstract

Tourette syndrome is a neurodevelopmental disorder commonly associated with involuntary movements, or tics. We currently lack an ideal animal model for Tourette syndrome. In humans, clinical manifestation of tics cannot be captured via functional imaging due to motion artefacts and limited temporal resolution, and electrophysiological studies have been limited to the intraoperative environment. The goal of this study was to identify electrophysiological signals in the centromedian (CM) thalamic nucleus and primary motor (M1) cortex that differentiate tics from voluntary movements. The data were collected as part of a larger National Institutes of Health-sponsored clinical trial. Four participants (two males, two females) underwent monthly clinical visits for collection of physiology for a total of 6 months. Participants were implanted with bilateral CM thalamic macroelectrodes and M1 subdural electrodes that were connected to two neurostimulators, both with sensing capabilities. MRI scans were performed preoperatively and CT scans postoperatively for localisation of electrodes. Electrophysiological recordings were collected at each visit from both the cortical and subcortical implants. Recordings collected from the CM thalamic ...Continue Reading

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Citations

Jul 13, 2020·Brain : a Journal of Neurology·Kara A JohnsonChristopher R Butson
Nov 28, 2020·Frontiers in Neurology·Maximilian KleimakerAlexander Münchau
Mar 5, 2021·Frontiers in Neurology·Sara MarcegliaDomenico Servello
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Apr 12, 2021·NeuroImage. Clinical·Alexander MünchauChristian Beste
Sep 21, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·Miguel WilkenMarcelo Merello
Oct 2, 2021·Journal of Neurology·José Fidel Baizabal-CarvalloJoseph Jankovic

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