PMID: 11905660Mar 22, 2002Paper

Differentiation and apoptosis induction therapy in acute promyelocytic leukaemia

The Lancet Oncology
Z Y Wang, Z Chen

Abstract

Induction of differentiation and/or apoptosis is a new and promising approach to cancer therapy, well illustrated by the treatment of acute promyelocytic leukaemia with all-trans-retinoic acid and arsenic compounds. Treatment with all-transretinoic acid results in complete remission in 92 - 95% of patients with this disease. Using the recently advocated combination of all-transretinoic acid and chemotherapy, adverse effects such as retinoic acid syndrome have decreased, and long-term survival has improved. Chemotherapy in combination with all-trans-retinoic acid seems to be the best postremission treatment protocol, with a 5-year relapse-free survival rate of 50 - 60%. Arsenic compounds have recently proved effective in newly diagnosed and relapsed acute promyelocytic leukaemia, with complete remission rates of 80 - 90% according to most reports. As2O3, the most studied arsenic compound, can be given by intravenous infusion at a dose of 0.08 - 0.16 mg/kg daily. A course of 28 - 44 days is required to induce remission. Although the drug is safe in patients who have relapsed, severe liver damage has been observed in some newly diagnosed patients. Combined use of chemotherapy and arsenic as postremission treatment results in longe...Continue Reading

References

Nov 5, 1998·The New England Journal of Medicine·S L SoignetR P Warrell
Apr 6, 1999·The Journal of Experimental Medicine·V Lallemand-BreitenbachH de Thé
Dec 28, 1999·Proceedings of the National Academy of Sciences of the United States of America·J ZhuH de Thé
May 11, 2013·Global Change Biology·Michael L LoganRyan G Calsbeek

❮ Previous
Next ❯

Citations

May 16, 2009·Molecular and Cellular Biochemistry·Clement G Yedjou, Paul B Tchounwou
Mar 3, 2007·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Zhu ChenYihuang Wang
Oct 25, 2007·Ophthalmic Research·Chunfang WangJost B Jonas
Jun 9, 2012·International Journal of Nanomedicine·Ye WangYi-Ping Hu
Mar 13, 2008·Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine·Jie ShenBing Li
Aug 8, 2007·Proceedings of the National Academy of Sciences of the United States of America·Yan LiGuangmei Yan
Jul 16, 2005·Hematology·Yair Gazitt, Cagla Akay
Jan 27, 2016·Biological Trace Element Research·Muthuraman PanduranganDoo Hwan Kim
Mar 21, 2009·Experimental Cell Research·James SmithAndrew Yen
Aug 9, 2008·Journal of the Neurological Sciences·Melissa W KoSteven L Galetta
Nov 17, 2009·The FEBS Journal·Huimin LuGuangmei Yan
Dec 22, 2015·The Lancet. Haematology·Vikram Mathews
Aug 23, 2011·Clinical Lymphoma, Myeloma & Leukemia·Alexander D DrilonAnupama Goel
Sep 10, 2008·Cell Biology International·Nan WangKui Wang
Oct 26, 2005·Leukemia Research·Karel SoucekAlois Kozubík
Nov 10, 2010·The American Journal of Chinese Medicine·Miao-Ju ChenMing-Feng Chen
Apr 27, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Miroslava DidiasovaMalgorzata Wygrecka
May 24, 2019·Internal Medicine·Akane KunitomiHirokazu Nagai
Oct 27, 2016·The Journal of Biological Chemistry·Kavin FatehchandSusheela Tridandapani
Nov 13, 2001·Oncogene·T D ZhangZ Chen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis