Differentiation and gene expression profile of tumor-associated macrophages

Seminars in Cancer Biology
Astrid SchmiederKai Schledzewski

Abstract

Tumor microenvironment is composed of proliferating neoplastic cells, a vascular network of endothelial cells, extra cellular matrix produced by fibroblasts, cellular compartments of adaptive immunity like lymphocytes and dendritic cells as well as cells of innate immunity, e.g., natural killer cells and macrophages. Many pre-clinical and clinical studies demonstrate an inversed correlation between macrophage infiltrate and patients' prognosis indicating a macrophage supporting role for tumor progression as producers of growth and angiogenic factors and as regulators of tissue remodelling. Based on in vitro models, macrophages have been classified in pro-inflammatory, classically activated macrophages (M1; stimulated by IFN-γ or LPS) and anti-inflammatory, alternatively activated macrophages (M2; stimulated by either IL-4/IL-13, IL-1β/LPS in combination with immune complexes or by IL-10/TGFβ/glucocorticoids). Tumor escape has been linked with a switch from M1 activation in the early tumor initiation process towards M2-like phenotype during tumor progression, a process that highlights the heterogeneity and plasticity of macrophage activation and which offers a possible therapeutic target directed against reversing the TAM phenot...Continue Reading

References

Apr 18, 1996·Nature·K TakedaS Akira
Aug 24, 1999·Cell·J F BrombergJ E Darnell
Dec 10, 1999·The Journal of Experimental Medicine·A HmadchaE Pintado
Mar 30, 2001·The Journal of Biological Chemistry·R PrevoD G Jackson
Feb 7, 2002·The Biochemical Journal·Oliver PolitzSergij Goerdt
Mar 20, 2002·Nature Reviews. Cancer·R A Gupta, R N Dubois
Apr 9, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Barbara GorgoniValeria Poli
May 11, 2002·Nature Reviews. Cancer·Michael KarinZhi-Wei Li
Jan 4, 2003·Nature Reviews. Immunology·Siamon Gordon
Jul 2, 2004·Nature Reviews. Cancer·Fran Balkwill
Jul 13, 2004·Seminars in Cancer Biology·Alberto MantovaniAntonio Sica
Nov 9, 2004·Trends in Immunology·Alberto MantovaniMassimo Locati
Jun 16, 2005·The Journal of Investigative Dermatology·Brian J NickoloffEli Pikarsky
Jul 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Thorsten HagemannFrances R Balkwill
Sep 10, 2005·International Journal of Cancer. Journal International Du Cancer·Feng-qiang WangDavid A Fishman
Oct 6, 2005·Proceedings of the National Academy of Sciences of the United States of America·Maria Grazia BorrelloMarco A Pierotti
Apr 6, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Thorsten HagemannFrances R Balkwill
May 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Julia KzhyshkowskaE Helene Sage
Sep 19, 2006·Genes & Development·Ksenya ShchorsGerard I Evan
Nov 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Fernando O MartinezAlberto Mantovani
May 9, 2007·Frontiers in Bioscience : a Journal and Virtual Library·Paraic A KennyMina J Bissell
May 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shaohua YuHuang-Ge Zhang
Aug 4, 2007·International Immunopharmacology·Keqiang ChenJi Ming Wang

❮ Previous
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Citations

Nov 8, 2012·Future Oncology·Jessica A CintoloBrian J Czerniecki
Mar 25, 2014·Immunology Letters·Alessandro PoggiMaria Raffaella Zocchi
Jul 6, 2014·Journal of Mammary Gland Biology and Neoplasia·Ashleigh UnsworthKara Britt
Dec 11, 2013·The Journal of Experimental Medicine·Michael J CavnarRonald P DeMatteo
Sep 3, 2013·Journal of Clinical and Experimental Hematopathology : JCEH·Bing BaiYoshihiro Komohara
Jul 11, 2013·Annals of Surgical Oncology·Jessica A CintoloGiorgos Karakousis
Apr 2, 2014·Hepatobiliary & Pancreatic Diseases International : HBPD INT·Ling Zhang, Cheng-Cai Wang
Feb 25, 2015·Journal of Bioinformatics and Computational Biology·Scott E NixonSandra L Rodriguez-Zas
Mar 5, 2016·Surgical Pathology Clinics·Mina L Xu, Yuri Fedoriw
Jul 24, 2012·Journal of the European Academy of Dermatology and Venereology : JEADV·E EmriE Remenyik
Nov 29, 2013·Journal of Cellular and Molecular Medicine·Francesco PantanoDaniele Santini
May 21, 2013·International Journal of Cancer. Journal International Du Cancer·Sylvia HartmannMartin-Leo Hansmann
Mar 4, 2014·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Sebastian Willenborg, Sabine A Eming
Aug 26, 2015·Seminars in Immunology·Joachim L SchultzeS Goerdt
Jan 30, 2015·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Moritz Felcht, Markus Thomas
Sep 30, 2014·Molecular Immunology·Gary EntricanDavid J Griffiths
Jul 16, 2015·BMC Veterinary Research·Breno C B BeirãoDavid J Argyle
May 6, 2016·Frontiers in Immunology·Kamar-Sulu N AtretkhanyMarina S Drutskaya
Dec 9, 2014·Human Vaccines & Immunotherapeutics·Amedeo AmedeiDomenico Prisco
Mar 26, 2013·Oncoimmunology·Oscar M Pello, Vicente Andrés
Jun 19, 2013·Current Opinion in Pharmacology·Jenny Cook, Thorsten Hagemann
Jun 20, 2012·Seminars in Cancer Biology·Viktor Umansky
Feb 27, 2013·The American Journal of Pathology·Jung S Byun, Kevin Gardner
May 16, 2014·Frontiers in Endocrinology·Ana I Pérez-HernándezGema Frühbeck
Nov 28, 2013·World Journal of Surgical Oncology·Marek StanczykMarek Maruszynski

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