Abstract
The purpose of this study was to differentiate by means of electrophysiologic study, a drug's ability to terminate or to prevent ventricular tachycardia (VT). Differences between the 2 effects were examined in patients with VT and the underlying mechanisms were studied in verapamil-responsive idiopathic sustained VT. The clinical significance of the distinction for chronic oral drug therapy is discussed. Thirty-five cases of inducible sustained VT were studied. A drug was considered "preventive" if it prevented VT induction and repetitive ventricular response, and "terminating" if it stopped induced VT within 15 complexes or could stop VT after its intravenous administration. Prevention and termination occurred together in 13 of 19 cases (68%) with disopyramide, in 10 of 19 cases (53%) with procainamide, in 8 of 12 cases (67%) with lidocaine, in 11 of 15 cases (73%) with mexiletine, and in 10 of 16 cases (63%) with verapamil. In the 16 in which verapamil terminated VT, VT rate immediately before termination slowed markedly from 167 +/- 33 to 134 +/- 28 beats/min. In the 6 cases without preventative effects, minimal and maximal premature intervals for VT induction increased significantly, from 291 +/- 70 to 335 +/- 85 ms and 323...Continue Reading
References
Mar 1, 1979·The American Journal of Cardiology·M E Josephson, L N Horowitz
Dec 1, 1978·Circulation·J W Mason, R A Winkle
Dec 1, 1978·Circulation·L N HorowitzA M Greenspan
Mar 1, 1988·Japanese Circulation Journal·H KasanukiK Hirosawa
Jan 1, 1986·Japanese Circulation Journal·H KasanukiK Hirosawa
Mar 1, 1985·Japanese Circulation Journal·H KasanukiK Hirosawa
Nov 1, 1984·Pacing and Clinical Electrophysiology : PACE·G J KleinR Yee
Dec 1, 1983·The American Journal of Cardiology·L D GermanJ J Gallagher
Nov 1, 1983·The American Journal of Cardiology·A E BuxtonM E Josephson
Jan 1, 1983·Japanese Circulation Journal·H KasanukiK Hirosawa
Jun 1, 1983·The American Journal of Cardiology·J W MasonL B Mitchell
Jul 1, 1983·The American Journal of Cardiology·F C LinD Wu
Aug 1, 1983·Circulation·C D SwerdlowJ W Mason
Jul 1, 1983·The Journal of Clinical Investigation·R J SungJ Davis
Dec 1, 1981·British Heart Journal·B BelhassenS Laniado
Apr 1, 1980·Chest·P DenesK M Rosen
Citations
Oct 23, 1997·Clinical Cardiology·L LinA B Curtis
Jun 1, 1995·Pacing and Clinical Electrophysiology : PACE·H KottkampM Borggrefe
Jun 1, 1993·Journal of Cardiovascular Electrophysiology·B Belhassen, S Viskin
Mar 1, 1994·Journal of Cardiovascular Electrophysiology·H KottkampG Breithardt
Nov 4, 2000·Journal of Cardiovascular Electrophysiology·H Kottkamp, G Hindricks
Dec 6, 2005·Resuscitation·UNKNOWN International Liaison Committee on Resuscitation
Apr 19, 2006·Pediatrics·UNKNOWN International Liaison Committee on Resuscitation