Differentiation and mechanisms of prevention and termination of verapamil-sensitive sustained ventricular tachycardia.

The American Journal of Cardiology
H KasanukiS Hosoda

Abstract

The purpose of this study was to differentiate by means of electrophysiologic study, a drug's ability to terminate or to prevent ventricular tachycardia (VT). Differences between the 2 effects were examined in patients with VT and the underlying mechanisms were studied in verapamil-responsive idiopathic sustained VT. The clinical significance of the distinction for chronic oral drug therapy is discussed. Thirty-five cases of inducible sustained VT were studied. A drug was considered "preventive" if it prevented VT induction and repetitive ventricular response, and "terminating" if it stopped induced VT within 15 complexes or could stop VT after its intravenous administration. Prevention and termination occurred together in 13 of 19 cases (68%) with disopyramide, in 10 of 19 cases (53%) with procainamide, in 8 of 12 cases (67%) with lidocaine, in 11 of 15 cases (73%) with mexiletine, and in 10 of 16 cases (63%) with verapamil. In the 16 in which verapamil terminated VT, VT rate immediately before termination slowed markedly from 167 +/- 33 to 134 +/- 28 beats/min. In the 6 cases without preventative effects, minimal and maximal premature intervals for VT induction increased significantly, from 291 +/- 70 to 335 +/- 85 ms and 323...Continue Reading

References

Mar 1, 1979·The American Journal of Cardiology·M E Josephson, L N Horowitz
Nov 1, 1984·Pacing and Clinical Electrophysiology : PACE·G J KleinR Yee
Dec 1, 1983·The American Journal of Cardiology·L D GermanJ J Gallagher
Nov 1, 1983·The American Journal of Cardiology·A E BuxtonM E Josephson
Jun 1, 1983·The American Journal of Cardiology·J W MasonL B Mitchell
Dec 1, 1981·British Heart Journal·B BelhassenS Laniado

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.