Abstract
Clinical and experimental experience indicate that differentiation and malignancy are inversely correlated. However, more recent experimental studies using mouse and human keratinocyte systems have demonstrated that complete or even substantial loss in overall epithelial differentiation is not a prerequisite for malignant growth of cancer cells. Major defects in differentiation are also not a prerequisite for premalignant stages, in particular for cell immortalization, which is considered an early and essential step in the transformation process. Moreover, progressive dedifferentiation, often associated with advanced tumor stages, is also found in immortalized cell lines which are, however, nontumorigenic. On the other hand, malignant cell lines may have maintained a high degree of their normal differentiation program and sensitivity to differentiation modulators. However, to date no transformed keratinocyte cell lines with completely normal differentiation have been observed. Since epidermal keratinization is a very complex process involving many different parameters and is fully expressed only under in vivo conditions, an exact and quantitative comparison of such ill-defined phenomena (differentiation and malignancy) is still...Continue Reading
Citations
Apr 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·M KobayashiY Fukui
Apr 13, 2004·Oncogene·Yutaka EnomotoTadahito Kanda
Jan 18, 2006·Annals of Surgical Oncology·Kenya YoshidaHideji Nakamura
Aug 4, 2009·PloS One·Kathy Qi CaiXiang-Xi Xu
Dec 1, 1996·Journal of Orofacial Orthopedics = Fortschritte Der Kieferorthopädie : Organ/official Journal Deutsche Gesellschaft Für Kieferorthopädie·G SchusterG Komposch
Dec 17, 2003·Oncogene·Dong-Chul KangPaul B Fisher
Mar 3, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H KogaM Sata
Mar 26, 2004·The Prostate·Kalipso HalkidouCraig N Robson
Jul 19, 2008·The FEBS Journal·Richard BauerT E Reichert
May 1, 1997·Journal of Periodontal Research·P TomakidiG Komposch
Oct 24, 2002·Blood·Ines SchweringRalf Küppers
Apr 8, 2004·World Journal of Gastroenterology : WJG·Jian-Ping KongZhi-Hua Liu
Oct 15, 1998·Experimental Cell Research·H P HohnH W Denker
May 3, 2021·European Journal of Pharmacology·Zahra MadadiSeyed Asadollah Mousavi
Aug 21, 2001·The Journal of Investigative Dermatology·T InoueH Sugihara
Aug 1, 1996·Journal of Virology·M A Ozbun, C Meyers
May 20, 2005·Differentiation; Research in Biological Diversity·Daniela Elena CosteaOlav Karsten Vintermyr