Differentiation-associated toxin receptor modulation, cytokine production, and sensitivity to Shiga-like toxins in human monocytes and monocytic cell lines.

Infection and Immunity
B Ramegowda, Vernon L Tesh

Abstract

Infections with Shiga toxin-producing Shigella dysenteriae type 1 or Shiga-like toxin (SLT)-producing Escherichia coli cause bloody diarrhea and are associated with an increased risk of acute renal failure and severe neurological complications. Histopathological examination of human and animal tissues suggests that the target cells for toxin action are vascular endothelial cells. Proinflammatory cytokines regulate endothelial cell membrane expression of the glycolipid globotriaosylceramide (Gb(3)) which serves as the toxin receptor, suggesting that the host response to the toxins or other bacterial products may contribute to pathogenesis by regulating target cell sensitivity to the toxins. We examined the effects of purified SLTs on human peripheral blood monocytes (PBMn) and two monocytic cell lines. Undifferentiated THP-1 cells were sensitive to SLTs. Treatment of the cells with a number of differentiation factors resulted in increased toxin resistance which was associated with decreased toxin receptor expression. U-937 cells, irrespective of maturation state, and PBMn were resistant to the toxins. U-937 cells expressed low levels of GB(3), and toxin receptor expression was not altered during differentiation. Treatment of mon...Continue Reading

References

May 15, 1976·International Journal of Cancer. Journal International Du Cancer·C Sundström, K Nilsson
Oct 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·T WaddellC A Lingwood
Aug 1, 1990·Microbial Pathogenesis·T J BarrettN A Strockbine
May 1, 1989·The Journal of Infectious Diseases·M JacewiczG T Keusch
Sep 1, 1988·Infection and Immunity·T G ObrigS W Rothman
Dec 1, 1985·Infection and Immunity·N A StrockbineA D O'Brien
Jan 1, 1980·Journal of Receptor Research·K Eiklid, S Olsnes
Aug 1, 1980·International Journal of Cancer. Journal International Du Cancer·S TsuchiyaK Tada

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Citations

Dec 19, 2000·Infection and Immunity·V M WolskiJ L Brunton
Feb 21, 2009·Journal of Cellular Physiology·Cristiano SalataGiorgio Palù
Feb 2, 2011·Infection and Immunity·Hui WangJames C Paton
Jul 7, 2012·Cellular and Molecular Life Sciences : CMLS·Andreas BauwensJohannes Müthing
Apr 24, 2015·Frontiers in Microbiology·Fumiko ObataTonya J Webb
Oct 3, 2001·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·W L MengelingH W Moon
Jul 5, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jennifer S GrayJames J Pestka
Feb 9, 2008·Journal of Biomedical Materials Research. Part a·Robert J SchutteW Monty Reichert
Mar 10, 2010·Future Microbiology·Vernon L Tesh
Apr 28, 2005·Biology of the Cell·Thomas Falguières, Ludger Johannes
Mar 31, 2010·Infection and Immunity·Dinorah Leyva-IlladesVernon L Tesh
Oct 15, 2014·Infection and Immunity·Teresa M DesRochersDavid L Kaplan
Jan 5, 2014·The Journal of Microbiology·Moo-Seung LeeVernon L Tesh
Jan 25, 2020·Toxins·Adrien JosephAlexandre Hertig
May 20, 2005·Gene Therapy·L Johannes, D Decaudin
Aug 23, 2003·Infection and Immunity·Ilze MatiseHarley W Moon
Jun 6, 2002·Traffic·Ludger Johannes, Christophe Lamaze
Nov 29, 2007·Current Opinion in Gastroenterology·Antonio Serna, Edgar C Boedeker
Nov 20, 2019·Pediatrics International : Official Journal of the Japan Pediatric Society·Masaki Shimizu
Oct 27, 2004·Infection and Immunity·Kellie R K WinterEvelyn A Dean-Nystrom
Jul 10, 2004·Molecular Plant-microbe Interactions : MPMI·Ron A SalzmanRay A Bressan

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