PMID: 376086Apr 1, 1979Paper

Differentiation between benign and malignant human lymph nodes by means of immunologic markers

Cancer
D B Brubaker, T L Whiteside

Abstract

A surface-marker assay combining immunofluorescence with anti-human immunoglobulin or anti-human brain serum (AHBS) and the formation of rosettes with untreated (E), antibody-sensitized (EA) and complement-coated (EAC) sheep erythrocytes was used to study mononuclear cell suspensions of human lymph nodes. The frequency of cells expressing more than one marker was increased in lymphoma nodes as compared to normal and hyperplastic nodes. The cells which simultaneously expressed complement receptors, surface immunoglobulin and the marker identified by AHBS represented the most prominent and characteristic subpopulation identified in neoplastic nodes. Distributions of cells with double and triple markers were studied by combining immunofluorescence with rosetting on frozen tissue sections. The multiple-marker cells had distributions that were characteristic in different human lymphomas. Benign and malignant human nodes could be distinguished on the basis of frequency and distribution of mononuclear cell populations carrying distinctive combinations of T- and B-cell surface markers.

References

Jan 1, 1977·Immunological Reviews·H Cantor, E A Boyse
Jan 1, 1977·Cellular Immunology·J A Stratton, P E Byfield
Mar 1, 1977·British Journal of Haematology·H M Chapel, N R Ling
Mar 1, 1976·The Journal of Clinical Investigation·T L Whiteside, B S Rabin
Aug 1, 1976·Seminars in Arthritis and Rheumatism·M A ScheinbergE S Cathcart
Jan 1, 1976·Scandinavian Journal of Immunology·C SamarutJ P Revillard
Nov 1, 1975·The Journal of Experimental Medicine·S M FuH G Kunkel
Oct 1, 1972·The Journal of Clinical Investigation·J WybranH H Fudenberg
Jan 1, 1972·Scandinavian Journal of Immunology·S S Fröland
Nov 28, 1973·Nature: New Biology·M F Greaves, G Brown
Jul 1, 1974·Journal of Immunological Methods·M E Kaplan, C Clark

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Citations

Apr 1, 1984·The British Journal of Ophthalmology·M G Alper, M Bray
Jul 1, 1984·Hematological Oncology·E AncelinF Huguet-Rigal
Jan 1, 1985·Journal of the American Academy of Dermatology·E M McMillan

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