Differentiation between dogs with thrombosis and normal dogs using the overall hemostasis potential assay

Journal of Veterinary Emergency and Critical Care
Anna L DengateChristopher M Ward

Abstract

To determine whether the overall hemostasis potential (OHP) and calibrated automated thrombogram (CAT) were significantly different between dogs with thrombosis and normal dogs. Ten dogs with clinical evidence of thromboembolic disease had both OHP and CAT performed. Forty healthy control dogs had OHP performed, and 23 of these also had CAT performed. Dogs with thrombosis had significantly higher OHP (P = 0.003), overall coagulation potential (P = 0.0001), and maximum optical density (Max OD, P < 0.0001) than normal dogs, and a significantly longer delay in the start of clot formation (P = 0.01). Max OD was higher than established reference intervals in 80% of the dogs with thrombosis. Using the CAT assay, dogs with thrombosis had a significantly longer lag time than normal dogs (P < 0.001). Plasma fibrinogen concentration correlated positively with overall coagulation potential, OHP, Max OD, and the slope of the OHP curve (P < 0.05), and was increased in 90% of dogs with thrombosis. The OHP assay findings were significantly different between normal dogs and those with thrombosis. CAT did not detect any significant differences between these populations of dogs, other than the lag time of the assay.

References

Jul 11, 2003·Pathophysiology of Haemostasis and Thrombosis·H Coenraad HemkerSuzette Béguin
Apr 15, 2010·Seminars in Thrombosis and Hemostasis·Philippe de MoerlooseMarguerite Neerman-Arbez
Oct 28, 2010·Seminars in Thrombosis and Hemostasis·Aleksandra Antovic
Apr 2, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Laure CarcaillonPierre-Yves Scarabin
Nov 19, 2011·Veterinary Clinical Pathology·Lara J RoseChristian Bédard
Jan 3, 2013·Journal of Veterinary Internal Medicine·L RoseC Bédard
Mar 6, 2013·The Journal of Small Animal Practice·N Bauer, A Moritz
Nov 28, 2013·American Journal of Veterinary Research·Anna L DengateChristopher M Ward

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Citations

Jan 18, 2019·Journal of Veterinary Emergency and Critical Care·Armelle deLaforcadeElizabeth Rozanski
Sep 13, 2021·Topics in Companion Animal Medicine·Silvia E Vargas-MoraRegina K Takahira

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