Differentiation between malignant and benign follicular adnexal tumours of the skin by DNA image cytometry

The British Journal of Dermatology
M VogelbruchP Kiehl

Abstract

We have demonstrated in previous studies that DNA image cytometry (DNA ICM) can be helpful in detecting malignancy in sebaceous tumours of the Muir-Torre syndrome and sweat gland tumours. However, little is known about DNA ICM in cutaneous adnexal tumours with follicular differentiation. To study a larger series of benign and malignant follicular adnexal tumours with DNA ICM. We studied 13 malignant follicular tumours (seven trichilemmal carcinomas, five malignant proliferating pilar tumours, one pilomatrix carcinoma) and 55 benign follicular tumours (four tumours of the follicular infundibulum, seven Winer's pores, eight trichilemmomas, two trichofolliculomas, 16 trichoepitheliomas, 13 pilomatrixomas, five trichoblastomas) by DNA ICM. All cases were clear-cut as malignant or benign, respectively, on histopathological criteria. The stemline interpretation according to Böcking et al. (DNA distribution in gastric cancer and dysplasia. In: Precancerous Conditions and Lesions of the Stomach, Zhang YC, Kawai K, eds. Berlin: Springer-Verlag, 1993: 103-20) was performed in all cases. In addition, 5[c]-exceeding events (5cEE) and the 2[c] deviation index (2cDI) were calculated, except in one histopathologically benign tumour, which rev...Continue Reading

References

May 1, 1992·Archives of Dermatology·A J Herzberg
Feb 1, 1990·The Journal of Investigative Dermatology·W StolzG Burg
Jun 1, 1988·The American Journal of Dermatopathology·R Jaworski
Oct 1, 1995·The British Journal of Dermatology·S BiesterfeldA Böcking
May 1, 1996·Human Pathology·C Cohen
Jan 1, 1995·Journal of Cellular Biochemistry. Supplement·B PalcicC E MacAulay
Jan 1, 1997·Dermatology : International Journal for Clinical and Investigative Dermatology·F DragoA Rebora
Jan 1, 1997·Dermatology : International Journal for Clinical and Investigative Dermatology·G NotoM Aricò
Jun 26, 1998·The British Journal of Dermatology·P KiehlA Böcking
May 3, 2000·The British Journal of Dermatology·M VogelbruchP Kiehl

❮ Previous
Next ❯

Citations

Aug 19, 2011·Plant Cell Reports·Milene Miranda Praça-FontesWellington Ronildo Clarindo
Apr 7, 2007·The American Journal of Dermatopathology·Omer GünhanUğur Berberoğlu
Apr 22, 2005·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Emily TierneyTeresa T Soriano
Dec 21, 2004·Journal of Cutaneous Pathology·Alexander J F LazarPhillip H McKee

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Basal Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Related Papers

APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica
Adem ElzagheidYrjo Collan
Archives of Dermatology
J G Casas, A Woscoff
Clinical and Experimental Dermatology
R GoirizA García-Díez
The American Journal of Dermatopathology
N KatoD J Santa Cruz
© 2022 Meta ULC. All rights reserved