PMID: 2816305Jan 1, 1989Paper

Differentiation in medulloblastomas: correlation between the immunocytochemical demonstration of photoreceptor markers (S-antigen, rod-opsin) and the survival rate in 66 patients

Acta Neuropathologica
M CzerwionkaW Schachenmayr

Abstract

Biopsy specimens of 66 medulloblastomas were investigated by means of S-antigen and rod-opsin immunocytochemistry. The patients were operated between 1969 and 1988 and the medical records were retrospectively evaluated to correlate the immunocytochemical features of the tumors to the course of the disease. S-antigen- and rod-opsin-immunoreactive tumor cells were found in 19 out of 66 cases. Since in the normal non-neoplastic state immunoreactive S-antigen and rod-opsin are restricted to retinal photoreceptors and a class of pinealocytes derived from photoreceptor cells, the occurrence of these proteins in certain tumor cells of medulloblastomas suggests a differentiation of these cells along the photoreceptor cell lineage and allows the identification of a special subtype of medulloblastoma displaying photoreceptor-specific characteristics. This subtype appears to be closely related to retinoblastomas and pineal cell tumors. The incidence of this subtype corresponds to approximately 30% of all medulloblastomas. Correlation between the demonstration of immunoreactive S-antigen and rod-opsin and the course of the disease revealed a 10-year survival rate of 50.6% for patients with medulloblastomas displaying photoreceptor-specific...Continue Reading

References

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Jan 1, 1986·Acta Neuropathologica·H W KorfW Schachenmayr
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Citations

Aug 1, 1994·Critical Reviews in Oncology/hematology·W M Molenaar, J Q Trojanowski
Oct 1, 1995·Neuropathology and Applied Neurobiology·S AlbrechtT Pietsch
Nov 26, 2009·PloS One·Sandro SantagataKeith L Ligon
May 1, 1995·Ultrastructural Pathology·W PapierzP P Liberski
Apr 27, 2010·Journal of Neuropathology and Experimental Neurology·Takahiro FukudaSaburo Saito
Sep 1, 1993·Human Pathology·D G DavisW R Markesbery
Apr 8, 2017·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Tenley C ArcherScott L Pomeroy
Mar 1, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M A GrotzerJ Q Trojanowski

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