PMID: 1309301Jan 1, 1992Paper

Differentiation markers in hemangiopericytoma

Cancer
Z Nemes

Abstract

Normal pericytes were found to express factor XIIIa (F-XIII) and histocompatibility antigen HLA-DR. These markers were studied in 15 hemangiopericytomas (HPC) and 16 other tumors with an HPC-like pattern. A subpopulation of tumor cells expressing F-XIII and HLA-DR antigens was a constant feature of HPC and supported their pericytic origin. Meningeal HPC did not differ in phenotype from peripheral soft tissue HPC. Most tumors with an HPC-like pattern (including synovial sarcomas, malignant schwannomas, leiomyosarcomas, and liposarcomas) were negative for F-XIII and HLA-DR. Malignant fibrous histiocytomas, however, invariably contained a subpopulation expressing these antigens. Therefore, F-XIII can be considered as a marker of fibrohistiocytic differentiation in HPC. Individual tumor cells in HPC occasionally were positive for factor VIII-related antigen (F-VIII-R-Ag), suggesting that the spectrum of differentiation in HPC may include the endothelial cell line. The differentiation characteristics of HPC support the concept that pericytes are primitive cells that may act as precursors to other mesenchymal cells.

References

Jan 1, 1976·Human Pathology·F M Enzinger, B H Smith
Mar 1, 1989·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·O SkalliL Orci
Jun 1, 1985·The Journal of Pathology·C E du Boulay
Jan 1, 1986·Tissue & Cell·D E Sims
Sep 1, 1974·Microvascular Research·E R Weibel
Dec 1, 1968·Cancer·T M MuradM S Murthy
Feb 1, 1969·Cancer·C Toker
May 1, 1969·Cancer·M A Venkatachalam, J G Greally
Jan 1, 1973·Cancer·M J HahnD J Joseph
Jun 1, 1968·The American Journal of Medicine·J J PaulladaM Doria-Medina
Dec 1, 1968·Journal of Ultrastructure Research·J A Rhodin
May 1, 1984·Pathology, Research and Practice·M TsuneyoshiM Enjoji
Mar 1, 1983·Journal of Neuropathology and Experimental Neurology·Y NakamuraA Marks
May 1, 1954·Cancer·C F BEGG, R GARRET
Jul 1, 1942·Annals of Surgery·A P Stout, M R Murray

❮ Previous
Next ❯

Citations

Oct 5, 2002·Cancer·N Joseph EspatMurray F Brennan
Jan 1, 1995·Surgery Today·N NodaM Akita
Jan 1, 1996·Pathology Oncology Research : POR·Jeannette TóthGábor Futó
Jul 10, 2004·Virchows Archiv : an International Journal of Pathology·T HansenC J Kirkpatrick
Mar 4, 2010·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Emanuela BinelloGeorge M Kleinman
Jan 17, 2004·International Journal of Pediatric Otorhinolaryngology·Khaled AlabdulhadiJohn J Manoukian
Jan 23, 1999·Research in Veterinary Science·Y MitaraiK Kadota
Jun 24, 1999·Thrombosis Research·L MuszbekZ Hevessy
Jul 14, 2001·Fitoterapia·E L Ghisalberti
Oct 28, 1998·The American Journal of Dermatopathology·A M Pollock, E C Sweeney
Sep 23, 1997·The American Journal of Surgical Pathology·N HirutaM Miura
Oct 19, 1999·The American Journal of Surgical Pathology·A L FolpeS W Weiss
Apr 20, 2002·Current Opinion in Infectious Diseases·Jose I. Figueroa
Nov 5, 1997·Journal of Pediatric Hematology/oncology·E M Flores-StadlerF Gonzalez-Crussi
Sep 1, 1993·Histopathology·M Malone
Oct 1, 1996·Journal of Cutaneous Pathology·L RequenaV Furio
Jun 1, 1994·The British Journal of Ophthalmology·S SujathaA B Tullo
Jun 1, 1994·The British Journal of Ophthalmology·B C Little
Mar 1, 1996·Neurosurgery·C AntoniadisG Fountzilas
Oct 1, 1996·Critical Reviews in Clinical Laboratory Sciences·L MuszbekH Mikkola
Jan 1, 1997·Pathology, Research and Practice·S Probst-CousinF Gullotta
Jun 7, 2011·The Spine Journal : Official Journal of the North American Spine Society·Paul D AckermanJohn F Shea
Jul 1, 1995·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·H SakashitaH Kurumaya
Aug 1, 1997·International Journal of Oral and Maxillofacial Surgery·H SakashitaK Nagao
Jan 7, 1998·Journal of the American Academy of Dermatology·L Requena, O P Sangueza
Aug 1, 1997·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·M PandeyD D Patel
Dec 31, 1997·American Journal of Ophthalmology·Z A KarciogluB G Haik
Jun 19, 2015·International Journal of Surgical Pathology·Jia ShenAaron W James
Dec 20, 2005·Histopathology·C Gengler, L Guillou

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.