Differentiation of atypical pancreatic neuroendocrine tumors from pancreatic ductal adenocarcinomas: Using whole-tumor CT texture analysis as quantitative biomarkers

Cancer Medicine
Jiali LiZhen Li

Abstract

To explore the application value of computed tomography (CT) texture analysis in differentiating atypical pancreatic neuroendocrine tumors (pNET) from pancreatic ductal adenocarcinomas (PDAC). This single-center retrospective study was approved by local institutional review board, and the requirement for informed consent was waived. We retrospectively analyzed 127 patients with 50 PDACs and 77 pNETs in pathology database between January 2012 and May 2017.These patients successfully finished preoperative contrast-enhanced CT test. Texture parameters (mean, median, 5th, 10th, 25th, 75th, 90th percentiles, skewness, kurtosis and entropy) were extracted from portal images and compared between PDAC and 77 pNET groups using proper statistical method. The optimal parameters for differentiating PDACs and atypical pNETs were gained through receiver operating characteristic (ROC) curves. On the basis of arterial enhancement, 52 pNETs (67%, 52/77) were typical hypervascular and 25 pNETs (32%, 25/77) were atypical hypovascular. Compared with PDACs, atypical pNETs had statistically higher mean, median, 5th, 10th, and 25th percentiles (P = 0.006, 0.024, 0.000, 0.001, 0.021, respectively) and statistically lower skewness (P = 0.017). However,...Continue Reading

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Citations

Apr 24, 2019·AJR. American Journal of Roentgenology·Linda C ChuElliot K Fishman
Aug 21, 2019·Abdominal Radiology·Saeed GhandiliLinda C Chu
Oct 22, 2020·Japanese Journal of Radiology·Marion BartoliPhilippe Soyer
Oct 24, 2020·Abdominal Radiology·Mohammed SalehAjaykumar C Morani
Nov 6, 2020·European Radiology·Bassam M AbunahelMaxim S Petrov
Nov 17, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Gen ChenZhen Li
Apr 10, 2021·European Journal of Nuclear Medicine and Molecular Imaging·C BezziM Picchio
Sep 30, 2020·Current Problems in Diagnostic Radiology·Linda C ChuElliot K Fishman
Jul 23, 2021·Abdominal Radiology·Mayur VirarkarPriya Bhosale
Aug 14, 2021·La Radiologia medica·Grigory KarmazanovskyAmiran Revishvili

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Methods Mentioned

BETA
dissection
dissections

Software Mentioned

Fire Voxel
CTTA
MedCalc
AW
Fire
SPSS

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