Differentiation of Autoimmune Pancreatitis from Pancreatic Cancer Remains Challenging

World Journal of Surgery
L D DickersonV S Yip

Abstract

Autoimmune pancreatitis (AIP) is an uncommon form of chronic pancreatitis. Whilst being corticosteroid responsive, AIP often masquerades radiologically as pancreatic neoplasia. Our aim is to appraise demographic, radiological and histological features in our cohort in order to differentiate AIP from pancreatic malignancy. Clinical, biochemical, histological and radiological details of all AIP patients 1997-2016 were analysed. The initial imaging was re-reviewed according to international guidelines by three blinded independent radiologists to evaluate features associated with autoimmune pancreatitis and pancreatic cancer. There were a total of 45 patients: 25 in type 1 (55.5%), 14 type 2 (31.1%) and 6 AIP otherwise not specified (13.3%). The median (IQR) age was 57 (51-70) years. Thirty patients (66.6%) were male. Twenty-six patients (57.8%) had resection for suspected malignancy and one for symptomatic chronic pancreatitis. Three had histologically proven malignancy with concurrent AIP. Two patients died from recurrent pancreatic cancer following resection. Multidisciplinary team review based on radiology and clinical history dictated management. Resected patients (vs. non-resected group) were older (64 vs. 53, p = 0.003) and ...Continue Reading

References

May 9, 1998·AJR. American Journal of Roentgenology·H IrieK Masuda
Nov 13, 2002·Gut·D MalkaP Ruszniewski
Nov 2, 2004·Virchows Archiv : an International Journal of Pathology·Giuseppe ZamboniGünter Klöppel
Oct 15, 2005·The American Journal of Surgical Pathology·Vikram DeshpandeGregory Y Lauwers
Jan 24, 2008·AJR. American Journal of Roentgenology·Naoki TakahashiSuresh T Chari
Apr 29, 2009·Gut·T KamisawaM Omata
Jul 2, 2009·The American Journal of Gastroenterology·Luca FrulloniItalo Vantini
Nov 3, 2010·Scandinavian Journal of Immunology·A W van ToorenenbergenH R van Buuren
Nov 5, 2010·World Journal of Gastroenterology : WJG·Kenji HiranoKazuhiko Koike
Jan 19, 2011·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Suresh T ChariTooru Shimosegawa
Mar 18, 2011·Pancreas·Tooru ShimosegawaUNKNOWN International Association of Pancreatology
Sep 7, 2011·Surgery·Peter A LearnWilliam R Jarnagin
May 9, 2012·Radiologic Clinics of North America·Rocio Perez-JohnstonDushyant V Sahani
Jul 7, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E J DuellP Boffetta
Jan 16, 2013·The American Journal of Gastroenterology·Masahiro ShiokawaTsutomu Chiba
Feb 5, 2014·Internal Medicine·Kenji HiranoKazuhiko Koike
Mar 17, 2015·Gastroenterology·Phil A HartSuresh T Chari
Apr 18, 2015·Medicine·Dai InoueYoh Zen
Jul 18, 2015·Clinical Journal of Gastroenterology·Kenji HiranoKazuhiko Koike
Sep 5, 2015·Digestion·Christine N ManserPeter Bauerfeind
Mar 6, 2016·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Antonio López-SerranoUNKNOWN Members of the Autoimmune Pancreatitis in Spain Study Group
Mar 8, 2016·Lancet·Shounak Majumder, Suresh T Chari
May 10, 2016·Nature Reviews. Disease Primers·Jorg KleeffJohn P Neoptolemos
Dec 29, 2016·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Kazuichi OkazakiTooru Shimosegawa
Nov 1, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E J DuellP Boffetta

❮ Previous
Next ❯

Citations

Nov 22, 2019·Abdominal Radiology·Arya Haj-MirzaianAtif Zaheer
Sep 9, 2020·Cancer Medicine·Gerda C M VreekerRob A E M Tollenaar
Jul 24, 2021·Digestive Diseases and Sciences·Hossein HaghbinMuhammad Aziz

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Related Papers

Case Reports in Gastroenterology
Raffaele PezzilliAndrea Imbrogno
Abdominal Radiology
Ashish KhandelwalNaoki Takahashi
Journal of Gastroenterology and Hepatology
Aravind Sugumar, Suresh T Chari
Minerva gastroenterologica e dietologica
R Catanzaro, A Dimartino
© 2022 Meta ULC. All rights reserved