Differentiation of Cardiac from Noncardiac Pleural Effusions in Cats using Second-Generation Quantitative and Point-of-Care NT-proBNP Measurements

Journal of Veterinary Internal Medicine
M HezzellMark A Oyama

Abstract

Pleural effusion is a common cause of dyspnea in cats. N-terminal pro-B-type natriuretic peptide (NT-proBNP) measurement, using a first-generation quantitative ELISA, in plasma and pleural fluid differentiates cardiac from noncardiac causes of pleural effusion. To determine whether NT-proBNP measurements using second-generation quantitative ELISA and point-of-care (POC) tests in plasma and pleural fluid distinguish cardiac from noncardiac pleural effusions and how results compare to the first-generation ELISA. Thirty-eight cats (US cohort) and 40 cats (UK cohort) presenting with cardiogenic or noncardiogenic pleural effusion. Prospective cohort study. Twenty-one and 17 cats in the US cohort, and 22 and 18 cats in the UK cohort were classified as having cardiac or noncardiac pleural effusion, respectively. NT-proBNP concentrations in paired plasma and pleural fluid samples were measured using second-generation ELISA and POC assays. The second-generation ELISA differentiated cardiac from noncardiac pleural effusion with good diagnostic accuracy (plasma: sensitivity, 95.2%, specificity, 82.4%; pleural fluid: sensitivity, 100%, specificity, 76.5%). NT-proBNP concentrations were greater in pleural fluid (719 pmol/L (134-1500)) than ...Continue Reading

References

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Citations

Nov 20, 2016·Annual Review of Animal Biosciences·Michael J MyersPhillip G Turfle
Sep 19, 2017·Journal of Feline Medicine and Surgery·Monica ProboWalter Bertazzolo
Apr 4, 2020·Journal of Veterinary Internal Medicine·Virginia Luis FuentesJoshua A Stern
Aug 22, 2020·Journal of Veterinary Internal Medicine·Joonbum SeoVirginia Luis Fuentes
Oct 25, 2017·Veterinary World·Gabriela Vieira de Lima, Felipp da Silveira Ferreira
Apr 4, 2021·Veterinary Sciences·Alessandra GavazzaMatteo Cerquetella

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Methods Mentioned

BETA
ELISA

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