PMID: 9179639Feb 1, 1997Paper

Differentiation of classical and novel antipsychotics using animal models

International Clinical Psychopharmacology
J ArntJ Hyttel

Abstract

The criteria that have been used to differentiate classical and atypical antipsychotics include measures of neurological and cognitive side effects and therapeutic effects. Novel antipsychotic compounds with few or no extrapyramidal syndromes (EPS) can be differentiated from classical neuroleptics by a number of animal models for limbic selectivity and dose-response separation between behavioral and pharmacological parameters analogous to EPS and antipsychotic effects. The results obtained using these models seem to be concordant with clinical findings. Moreover, animal models expand our understanding of the pharmacological mechanisms responsible for EPS and for the therapeutic effects of antipsychotics, and they allow an examination of the possible effects of new compounds on cognition. Here we review a number of key reports on the differentiation of classical and novel antipsychotics using animal models.

Citations

Jul 16, 2003·European Journal of Pharmacology·Satoru NakaiTetsuro Kikuchi
Jun 6, 2000·Pharmacology, Biochemistry, and Behavior·M Rodríguez-AriasJ Miñarro
Jul 31, 2009·European Psychiatry : the Journal of the Association of European Psychiatrists·G MarcheseL Pani
Dec 15, 2010·CNS Neuroscience & Therapeutics·Magdalena Nord, Lars Farde
Nov 2, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ofer AgidShitij Kapur
Dec 2, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Sridhar NatesanShitij Kapur
Feb 28, 2003·The Journal of Pharmacology and Experimental Therapeutics·Shitij KapurJose N Nobrega
Apr 26, 2000·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·G Remington

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