PMID: 9444329Jan 1, 1997Paper

Differentiation of Coxiella burnetii by sequence analysis of the gene (com1) encoding a 27-kDa outer membrane protein

Microbiology and Immunology
G Q ZhangK Hirai

Abstract

The gene (com1) encoding a 27-kDa outer membrane protein in 21 strains of Coxiella burnetii from a variety of clinical and geographical sources was sequenced for strain differentiation. The com1 gene was highly conserved among all the strains tested but there were several differences in nucleotide and deduced amino acid sequences. Based on the com1 gene-specific nucleotides and deduced amino acids, the 21 strains were divided into four groups. Group 1 contained 14 strains originating from ticks, cattle and human cases of acute Q fever. Groups 2 and 3 included 2 and 3 strains, respectively, originating from human cases of chronic Q fever. Group 4 contained 2 strains originating from a human case of acute Q fever and a goat with abortion. The results indicated that the strains originating from ticks, cattle and human cases of acute Q fever differed at the molecular level from those of human chronic Q fever. This study suggests that a sequence analysis of the com1 gene can be used for strain differentiation of C. burnetii.

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Citations

Feb 24, 2006·Infection and Immunity·Amélie HonstettreJean-Louis Mege
Apr 12, 2003·Journal of Clinical Microbiology·Akitoyo HottaKatsuya Hirai
May 8, 2003·Journal of Clinical Microbiology·Robert E Brennan, James E Samuel
Dec 12, 2012·BMC Veterinary Research·Ianire AstobizaCorné H W Klaassen
Oct 18, 2014·Vector Borne and Zoonotic Diseases·Marco Di DomenicoCesare Cammà
Jan 6, 2016·Canadian Journal of Microbiology·Samira BoarbiMarcella Mori
Dec 22, 2004·Microbiology and Immunology·Masako AndohKatsuya Hirai
Feb 23, 2011·Letters in Applied Microbiology·M G LockhartJ Stenos
Sep 1, 2015·Veterinary Microbiology·R Van den BromP Vellema
Jan 22, 2014·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Durga Prasad DasS B Barbuddhe
Feb 1, 2006·FEMS Microbiology Letters·Sanela SvrakaWieger L Homan
Dec 14, 2006·European Journal of Immunology·Soraya MeghariJean-Louis Mege
Nov 23, 2006·Annals of the New York Academy of Sciences·Noriyuki TatsumiKazuo Yamaguchi
Aug 26, 1998·The Journal of Veterinary Medical Science·K Hirai, H To

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