PMID: 39714Jan 1, 1978

Differentiation of drugs acting centrally upon the cardiovascular system by means of sympathetic and vagal responses

Clinical and Experimental Hypertension : CHE
W Kobinger, L Pichler

Abstract

The response pattern of the autonomic nervous system was investigated after central administration (intra-cisternal, vertebral artery) of amphetamine, morphine, fentanyl, dextromoramide and the substance R 28935, chemically related to the neuroleptic agent pimozide. Effects on the sympathetic system were measured by recording electrical discharges of fibres of the (preganglionic) major splanchnic nerve in anaesthetized cats; those on the vagal system by recording the heart rate in anaesthetized dogs under beta-adrenoceptor blockade; the baroreceptor reflex was elicited by the blood pressure increase of i.v. injected angiotensin. All substances decreased the spontaneous discharge rate of the splanchnic nerve. Amphetamine facilitated the vagally mediated reflex bradycardia and this was antagonized by the alpha-adrenoceptor blocking agent piperoxan. Amphetamine did not affect the resting heart rate, as has already been shown for clonidine and related substances. The narcotic analgesics lowered the resting heart rate but did not facilitate the baroreceptor reflex response. R 28935 neither influenced resting heart rate nor the baroreceptor reflex response in beta-blocked dogs. On the basis of the vagal response pattern it was theref...Continue Reading

References

Feb 1, 1977·Naunyn-Schmiedeberg's Archives of Pharmacology·M LaubieM Drouillat
Aug 1, 1976·Naunyn-Schmiedeberg's Archives of Pharmacology·C GomesG Trolin
Jan 1, 1966·British Journal of Pharmacology and Chemotherapy·S O Kayaalp, S Kaymakçalan
Aug 1, 1972·European Journal of Pharmacology·W Kobinger, A Walland
Feb 1, 1974·European Journal of Pharmacology·J KorfG K Aghajanian
May 1, 1973·European Journal of Pharmacology·H Schmitt, S Fenard
Nov 1, 1970·The American Journal of Physiology·L R Klevans, G L Gebber
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Citations

Nov 1, 1980·Naunyn-Schmiedeberg's Archives of Pharmacology·M C Koss
Sep 1, 1980·Naunyn-Schmiedeberg's Archives of Pharmacology·B Persson
Oct 1, 1982·Naunyn-Schmiedeberg's Archives of Pharmacology·H Kitagawa, A Walland
Jan 8, 1985·European Journal of Pharmacology·L Pichler, W Kobinger
Aug 1, 1992·Pharmacology, Biochemistry, and Behavior·C W SchindlerS R Goldberg
Jan 1, 1990·Pharmacology & Therapeutics·D P Agarwal, H W Goedde
Jul 12, 1995·Annals of the New York Academy of Sciences·D J ReisS Regunathan
Jul 1, 1988·British Journal of Pharmacology·J A HeyM C Koss
Nov 1, 1979·Naunyn-Schmiedeberg's Archives of Pharmacology·M C Koss
Jan 1, 1982·The Journal of Pharmacy and Pharmacology·H E ConnorL Finch
Feb 1, 1986·Naunyn-Schmiedeberg's Archives of Pharmacology·W Kobinger

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