Differentiation of early hepatocellular carcinoma from benign hepatocellular nodules on gadoxetic acid-enhanced MRI.

The British Journal of Radiology
Hyungjin RheeKyung-Sik Kim

Abstract

To test new diagnostic criteria for the discrimination of early hepatocellular carcinoma (HCC) from benign hepatocellular nodules on gadoxetic acid-enhanced MRI (Gd-EOB-MRI). We retrospectively analysed 34 patients with 29 surgically diagnosed early HCCs and 31 surgically diagnosed benign hepatocellular nodules. Two radiologists reviewed Gd-EOB-MRI, including diffusion-weighted imaging (DWI), and the signal intensity at each sequence, presence of arterial enhancement and washout were recorded. We composed new diagnostic criteria based on the lesion size and MRI findings, and then the diagnostic performance was compared with that of conventional imaging criteria with logistic regression and a generalised estimating equation method. A size cut-off value (≥1.5 cm diameter) and MRI findings of T(1) hypointensity, T(2) hyperintensity, DWI hyperintensity on both low and high b-value images (b=50 and 800 s mm(-2), respectively), arterial enhancement, late washout and hepatobiliary hypointensity were selected as the diagnostic criteria. When lesions were considered malignant if they satisfied three or more of the above criteria, the sensitivity was significantly higher than when making a diagnosis based on arterial enhancement and wash...Continue Reading

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Citations

Aug 5, 2014·Magnetic Resonance Imaging Clinics of North America·Daniel C Barr, Hero K Hussain
Dec 3, 2014·Surgical Oncology Clinics of North America·Kathryn J FowlerDavid Linehan
Dec 26, 2015·Canadian Association of Radiologists Journal = Journal L'Association Canadienne Des Radiologistes·Emily H T PangSilvia D Chang
Sep 1, 2015·Radiologic Clinics of North America·Mustafa R Bashir, Hero K Hussain
Aug 12, 2014·Journal of Magnetic Resonance Imaging : JMRI·Utaroh MotosugiScott B Reeder
Jun 24, 2015·AJR. American Journal of Roentgenology·Byung Ihn ChoiValérie Vilgrain
Dec 28, 2016·AJR. American Journal of Roentgenology·Moon Hyung ChoiChandana Lall
Feb 23, 2019·European Radiology·Myeong-Jin KimChansik An
Jan 15, 2014·Expert Review of Gastroenterology & Hepatology·Ahmed Ba-SsalamahFilipe Caseiro Alves
Jul 24, 2020·Journal of Magnetic Resonance Imaging : JMRI·Jae Hyun KimJeong Min Lee
Aug 26, 2020·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Naoki MatsumotoMasahiko Sugitani
Jul 5, 2019·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Jae Hyun KimJeong Min Lee
Mar 6, 2017·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Jonathon WillattF Syed
May 28, 2020·La Radiologia medica·Matteo BarabinoGianpaolo Carrafiello
Jun 7, 2017·Canadian Association of Radiologists Journal = Journal L'Association Canadienne Des Radiologistes·Elena P ScaliSilvia D Chang
Apr 3, 2014·Topics in Magnetic Resonance Imaging : TMRI·Daniel C Barr, Hero K Hussain
Mar 5, 2021·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Michael Vinchill ChanJessica Yang

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