Differentiation of extramedullary acute promyelocytic leukemia by all-trans-retinoic acid

Leukemia & Lymphoma
C A LedermanE J Feldman

Abstract

The effect of all-trans-retinoic acid (ATRA) on extramedullary acute promyelocytic leukemia (APL) has not been fully delineated. We report an unusual case of APL in which a patient relapsed in the skin and central nervous system. Cytodifferentiation of leukemic cells from these extramedullary sites was demonstrated following treatment with ATRA.

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Citations

Dec 15, 1996·Cancer·P H WiernikJ P Dutcher
Aug 1, 1997·Cancer·M BenekliI C Haznedaroglu
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Jun 23, 2006·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P RaananiI Ben-Bassat

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