Differentiation of Fibroadenomas and Pure Mucinous Carcinomas on Dynamic Contrast-Enhanced MRI of the Breast Using Volume Segmentation for Kinetic Analysis: A Feasibility Study

AJR. American Journal of Roentgenology
Romuald FerréBenoît Mesurolle

Abstract

The objective of this study was to retrospectively evaluate the diagnostic performance of volume-based kinetic analysis in dynamic contrast-enhanced MRI (DCE-MRI) of the breast for the differentiation of fibroadenomas (FAs) with high T2 signal intensity from pure mucinous carcinomas (PMCs). A review of records from 2007 to 2013 that were stored in the pathology department database at our institution identified nine patients with PMCs (defined as tumor cells with a mucinous component ≥ 90%) who underwent preoperative breast MRI. The PMCs were compared with 15 biopsy-proven FAs from 13 patients. Characteristics noted on DCE-MRI were evaluated using computer-assisted diagnosis software. For each mass, the proportion of progressive enhancement in the lesion at the delayed phase was quantified. Both groups of masses were compared using a Wilcoxon signed rank test. A ROC curve was used to define an appropriate cutoff point. The median rate of progressive enhancement was 100% (range, 99-100%) for FAs and 97% (range, 87-99%) for PMCs (p = 0.0326). The AUC of the kinetic curve for progressive enhancement was 0.7519 (95% CI, 0.5258-0.9407). A more appropriate cutoff value to maximize sensitivity and specificity was 98.5%. With this cutof...Continue Reading

References

Aug 1, 1995·AJR. American Journal of Roentgenology·T E WilsonL K Joynt
Dec 6, 2000·Journal of Magnetic Resonance Imaging : JMRI·C K Kuhl, H H Schild
Jun 22, 2002·AJR. American Journal of Roentgenology·Miho KawashimaShiro Sugihara
Mar 25, 2004·AJR. American Journal of Roentgenology·W W M LamT K Ma
Mar 26, 2004·American Journal of Surgery·Ian K KomenakaFreya R Schnabel
Jun 24, 2006·AJR. American Journal of Roentgenology·Constance D LehmanXiaoming Chen
Sep 12, 2006·European Journal of Radiology·Takashi OkafujiHiroshi Honda
Nov 15, 2006·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Katarzyna J MacuraDavid A Bluemke
Sep 4, 2009·European Radiology·Carla MeeuwisWouter B Veldhuis
Mar 17, 2010·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Gorane SantamaríaPedro Luis Fernández
May 29, 2010·Journal of Digital Imaging·Shannon C AgnerAnant Madabhushi
Nov 13, 2010·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Jung Lim YooEun-Young Kang
May 17, 2012·Radiology·Mary C MahoneyConstance Lehman
Sep 4, 2012·European Journal of Radiology·C DromainC Balleyguier
Feb 22, 2014·AJR. American Journal of Roentgenology·Christine WestraRonald L Eisenberg

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Related Papers

Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Philippe PuechLaurent Lemaitre
© 2022 Meta ULC. All rights reserved