Differentiation of Glial Cells From hiPSCs: Potential Applications in Neurological Diseases and Cell Replacement Therapy

Frontiers in Cellular Neuroscience
Wei ZhengZhiguo Chen

Abstract

Glial cells are the most abundant cell type in the central nervous system (CNS) and play essential roles in maintaining brain homeostasis, forming myelin, and providing support and protection for neurons, etc. Over the past decade, significant progress has been made in the reprogramming field. Given the limited accessibility of human glial cells, in vitro differentiation of human induced pluripotent stem cells (hiPSCs) into glia may provide not only a valuable research tool for a better understanding of the functions of glia in the CNS but also a potential cellular source for clinical therapeutic purposes. In this review, we will summarize up-to-date novel strategies for the committed differentiation into the three major glial cell types, i.e., astrocyte, oligodendrocyte, and microglia, from hiPSCs, focusing on the non-neuronal cell effects on the pathology of some representative neurological diseases. Furthermore, the application of hiPSC-derived glial cells in neurological disease modeling will be discussed, so as to gain further insights into the development of new therapeutic targets for treatment of neurological disorders.

References

Oct 1, 1977·Archives of Neurology·S G Waxman
Jul 1, 1992·Journal of Neuroscience Research·M G EnnasF Gremo
Feb 6, 1986·Nature·C Ffrench-Constant, M C Raff
Oct 28, 1997·Archives of Neurology·R H Brown
Sep 14, 1999·Brain Research Bulletin·J W Fawcett, R A Asher
Nov 11, 1999·Proceedings of the National Academy of Sciences of the United States of America·J YrjänheikkiJ Koistinaho
Feb 7, 2001·Science·E M UllianB A Barres
May 24, 2001·Current Opinion in Neurology·C Bjartmar, B D Trapp
Jun 2, 2001·The New England Journal of Medicine·L P Rowland, N A Shneider
Nov 21, 2001·Nature Reviews. Neuroscience·S C Zhang
Jan 18, 2002·The New England Journal of Medicine·Ansi ChangBruce D Trapp
Oct 3, 2003·Trends in Neurosciences·Maiken NedergaardSteven A Goldman
Oct 24, 2003·Molecular and Cellular Neurosciences·Mary R L DawsonRichard Reynolds
Apr 16, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Alain R Simard, Serge Rivest
Jun 26, 2004·Annual Review of Neuroscience·Lucie I BruijnDon W Cleveland
Aug 21, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Istvan PirkoMoses Rodriguez
Dec 17, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Anne RoumierAlain Bessis
Feb 3, 2005·Nature Biotechnology·Xue-Jun LiSu-Chun Zhang
Feb 25, 2005·The Journal of Experimental Medicine·Kazuya TakahashiHarald Neumann
Mar 26, 2005·Development·Matthew FogartyNicoletta Kessaris
Dec 22, 2005·Journal of Anatomy·Akiko NishiyamaArthur Butt
Jan 3, 2006·Nature Neuroscience·Nicoletta KessarisWilliam D Richardson
Apr 29, 2006·Journal of Biology·Jeannette E DaviesStephen J A Davies
Jun 3, 2006·Science·Séverine BoilléeDon W Cleveland
Aug 30, 2006·Trends in Neurosciences·Nancy Ann OberheimMaiken Nedergaard
Aug 30, 2006·Proceedings of the National Academy of Sciences of the United States of America·Chet C SherwoodPatrick R Hof
Sep 12, 2006·Current Opinion in Neurobiology·Martin Paukert, Dwight E Bergles
Oct 3, 2006·Molecular and Cellular Neurosciences·Benxiu JiJane K Relton
Jan 19, 2007·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Akiko Nishiyama
Apr 21, 2007·Annals of Neurology·Alberto Ascherio, Kassandra L Munger
May 12, 2007·Annals of Neurology·Alberto Ascherio, Kassandra L Munger
May 29, 2007·Nature Biotechnology·Kiichi WatanabeYoshiki Sasai
Jun 9, 2007·Journal of Neurochemistry·Qin XiaoStanley H Appel
Jul 24, 2007·Nature Genetics·Celia M KassmannKlaus-Armin Nave

❮ Previous
Next ❯

Citations

May 29, 2020·The European Journal of Neuroscience·Abdallah Mohammad IbrahimJ B Senthil Kumar
Feb 28, 2019·Frontiers in Cellular Neuroscience·Ulla-Kaisa PeteriMaija L Castrén
Mar 3, 2020·Frontiers in Veterinary Science·Suryo KuncorojaktiChenphop Sawangmake
Apr 8, 2020·Proceedings of the National Academy of Sciences of the United States of America·Sara Palma-TortosaZaal Kokaia
Sep 3, 2019·Frontiers in Cellular Neuroscience·Goutam Kumar TantiBernhard Hemmer
Aug 28, 2020·Frontiers in Cellular Neuroscience·Daniela Espinosa-HoyosKrystyn J Van Vliet
Dec 16, 2019·Neuroscience Letters·Ekta P MakhijaKrystyn J Van Vliet
Feb 13, 2021·Brain Sciences·Ulla-Kaisa PeteriMaija L Castrén
Apr 1, 2021·Journal of Biomedical Nanotechnology·Kai YeJiabo Hu
Mar 23, 2019·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Xinwen ZhangXin Qi
May 28, 2021·Frontiers in Cell and Developmental Biology·Raj BoseGary L Dunbar

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic

Clinical Trials Mentioned

NCT03482050
NCT02943850
NCT02302157
NCT01407211
NCT01225289
NCT01952483
NCT01803867
NCT02398461
NCT00001669
NCT00283023

Related Concepts

Related Feeds

Astrocytes & Neurodegeneration

Astrocytes are important for the health and function of the central nervous system. When these cells stop functioning properly, either through gain of function or loss of homeostatic controls, neurodegenerative diseases can occur. Here is the latest research on astrocytes and neurodegeneration.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.