PMID: 9434599Jan 22, 1998Paper

Differentiation of human gastric adenocarcinoma cell line MGc80-3 induced by verbascoside

Planta medica
J LiRongliang Zheng

Abstract

Verbascoside is a natural antioxidant extracted from Pedicularis striata Pall (Jueyehesen). After being treated with 20 mumol/l verbascoside, the growth curve and mitotic index of human gastric adenocarcinoma MGc80-3 cells decreased remarkably, cell doubling time was delayed, the cellular growth inhibitory rate amounted to 53.2%, cell surface charge assayed by cell electrophoresis obviously changed, the electrophoresis rate dropped from 3.51 microns/s/v/cm to 2.74, i.e., the percent of retardation reached 28.4%. There was a 75% decrease of the tumorigenicity for the treated cells compared with the untreated cells inoculated subcutaneously in BALB/C nude mice. Scanning electron microscopy revealed that the microvilli on the surface of treated cells had been reduced obviously. It confirmed that verbascoside, similar to DMSO, could reverse MGc80-3 cells' malignant phenotypic characteristics and induced redifferentiation of MGc80-3 cells.

Citations

Oct 3, 2000·Phytochemistry·Y M LiD Y Zhu
Apr 26, 2000·Biochimica Et Biophysica Acta·Y ShiR Zheng
Feb 19, 2011·European Journal of Applied Physiology·Antonia Mestre-AlfaroAntoni Pons
Nov 2, 2007·Basic & Clinical Pharmacology & Toxicology·Ping MuRong-Liang Zheng
Oct 4, 2005·The Journal of Steroid Biochemistry and Molecular Biology·Zoi PapoutsiParaskevi Moutsatsou
Dec 27, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Luis Felipe Santos-CruzMaría Eugenia Heres-Pulido
May 24, 2012·Journal of Agricultural and Food Chemistry·V Sánchez de MedinaM D Luque de Castro
Jun 20, 2002·SAR and QSAR in Environmental Research·O SperandioN El Fassi
Feb 7, 2003·SAR and QSAR in Environmental Research·O DelalandeJ P Doucet

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