PMID: 7539466Jun 1, 1995Paper

Differentiation of human trophoblast populations involves alterations in cytokeratin patterns

The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society
J MühlhauserM Castellucci

Abstract

Cytokeratins (CKs) are related to proliferation and differentiation of epithelial cells. Little knowledge exists about CK patterns in human trophoblast subpopulations (villous and extravillous trophoblasts). To better understand differentiation and function of trophoblast components, we studied the distribution patterns of CKs in the placenta throughout pregnancy. A panel of well-defined monoclonal antibodies against different types of cytokeratins, vimentin, and fibrin, was used on frozen and paraffin sections. CK8, 18, and 19 were expressed in all the villous and extravillous trophoblastic subsets throughout pregnancy. In the first trimester, syncytiotrophoblasts were positive for CK7 and 13 along the basal membrane. As pregnancy progressed there was an increase in intensity of the reaction product and a more diffuse positive staining of CK7 in the cytoplasm of the syncytium, with evident positivity along the apical membrane. CK13 showed similar expression as CK7, but with less intense staining along the apical membrane and less prominent staining in the cytoplasm. Villous cytotrophoblasts were also positive for CK7 and CK13. CK17 was found related to cytotrophoblastic cells in contact with or next to fibrin deposits. Extravi...Continue Reading

Citations

Jan 29, 2014·Reproductive Biology and Endocrinology : RB&E·Alexandre U BorbelyEstela Bevilacqua
May 17, 2011·The Journal of Membrane Biology·Gloria RiquelmeCarolina Rodríguez
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