Differentiation of hypertrophic cardiomyopathy from other forms of left ventricular hypertrophy by means of three-dimensional echocardiography

The American Journal of Cardiology
Stefano CaselliStefano De Castro

Abstract

In clinical practice, differential diagnosis among different forms of left ventricular (LV) hypertrophy is not always easy, and hypertrophic cardiomyopathy (HC) can be misdiagnosed. In this study, it was hypothesized that a 3-dimensional echocardiographically derived index of LV regional mass distribution could be useful in differentiating HC from other forms of LV hypertrophy. Sixty-eight subjects underwent 2- and 3-dimensional echocardiography; of these, 20 were healthy volunteers, 18 were top-level athletes, 15 had essential hypertension, and 15 had HC. In off-line analysis, a 12-segment model was generated for segmental mass measurement. A mass dispersion index (MDI) was calculated as the average of the SDs of segmental mass values at the basal, middle, and apical layers. The ratio of ventricular septal thickness to posterior wall thickness was also calculated using 2-dimensional echocardiography. Patients with HC had significantly higher MDI values (1.75 +/- 0.43) than healthy volunteers (0.39 +/- 0.13) (p <0.0001), athletes (0.49 +/- 0.12) (p <0.0001), and patients with hypertension (0.38 +/- 0.10) (p <0.0001). The ratio of ventricular septal thickness to posterior wall thickness was significantly higher in patients with ...Continue Reading

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Citations

Jun 21, 2012·Sports Medicine·Eugene Sun Yim, Gianmichael Corrado
Jun 5, 2012·Seminars in Roentgenology·Elana Koss, Mario J Garcia
Apr 26, 2011·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Sherif F NaguehUNKNOWN Society of Cardiovascular Computed Tomography
May 10, 2011·The American Journal of Cardiology·Stefano CaselliAntonio Pelliccia
Apr 10, 2009·JACC. Cardiovascular Imaging·Andre La GercheDavid L Prior
Aug 16, 2016·Cardiovascular Ultrasound·Vito Maurizio ParatoUNKNOWN Italian Chapter of ISCU
Nov 6, 2009·European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology·L K WilliamsR P Steeds
Jan 24, 2018·Journal of Applied Physiology·Fatih YalçinTheodore P Abraham
Apr 18, 2020·Journal of Echocardiography·Leonard MandeşBogdan A Popescu

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