Differentiation of isomeric heptylamines by in-source collision-induced dissociation of [M + H]+ ions

Rapid Communications in Mass Spectrometry : RCM
Iga ZarembaMałgorzata Kasperkowiak

Abstract

1,3-Dimethylamylamine (1,3-DMAA), 1,4-dimethylamylamine (1,4-DMAA) and 2-aminoheptane are isomeric heptylamines commonly used as stimulants. The fragmentations of their [M + H]+ ions (m/z 116) are almost identical and consist of the formation of a fragment ion C4 H9+ at m/z 57. It is interesting to check if analysis of electrospray ionization (ESI) mass spectra of these three amines enables their differentiation. In order to better understand the fragmentation of isomeric heptylamines, 1-, 3- and 4-aminoheptane were also included in the study. ESI in-source collision-induced dissociation (CID) mass spectra were obtained with a Waters/Micromass ZQ2000 mass spectrometer (single quadrupole-type instrument) at a cone voltage of 12-34 V. The influence of three commonly used solvents on the fragmentation of [M + H]+ ions was tested, namely methanol, methanol/water (1/1) and acetonitrile/water (1/1). Only one quantitative difference was observed in the mass spectra of 1,3-DMAA, 1,4-DMAA and 2-aminoheptane, namely formation of a product ion at m/z 57 from the [M + H]+ ion of 1,3-DMAA is more efficient than the formation of this ion from [M + H]+ ions of 2-aminoheptane and 1,4-DMAA. In-source CID of 3- and 4-aminoheptane consists of (be...Continue Reading

References

Sep 25, 1999·Journal of the American Society for Mass Spectrometry·W WeinmannM Svoboda
Sep 7, 2001·Rapid Communications in Mass Spectrometry : RCM·J MakowieckiJ Jalonen
Apr 11, 2003·Journal of the American Society for Mass Spectrometry·Wendi M David, Jennifer S Brodbelt
Sep 21, 2007·European Journal of Mass Spectrometry·Mario ThevisWilhelm Schänzer
Oct 6, 2009·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Laurent PerrenoudChristophe Saudan
Dec 8, 2011·Drug Testing and Analysis·A LisiC Goebel
Sep 4, 2012·Drug Testing and Analysis·Chiara Di LorenzoPatrizia Restani
May 25, 2013·Drug Testing and Analysis·Krista G AustinHarris R Lieberman
Jul 31, 2013·Forensic Science International : Synergy·Viorica Lopez-Avila, Mirela Zorio
Oct 30, 2013·Drug Testing and Analysis·Ashton D LesiakJason R E Shepard
Feb 3, 2015·Drug Testing and Analysis·John R H ArcherAndrew T Kicman
Jun 19, 2015·Journal of AOAC International·Bharathi AvulaIkhlas A Khan
Nov 9, 2017·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Pieter A CohenBastiaan J Venhuis

❮ Previous
Next ❯

Citations

Nov 12, 2021·Rapid Communications in Mass Spectrometry : RCM·Peixi ZhuErwin Adams

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.