Differentiation of lisinopril and its RSS diastereomer by liquid chromatography combined with collision-induced dissociation mass spectrometry

Journal of Mass Spectrometry : JMS
Cuirong SunYuanjiang Pan

Abstract

A simple and sensitive liquid chromatography tandem multiple-stage mass spectrometry (HPLC/MS/MS) method suitable for bulk lisinopril analysis was developed, by which lisinopril and its RSS isomer were separated and differentiated. In the collision-induced dissociation (CID) mass spectra of the [M + H](+) ions, the abundance of the fragment ion of m/z 246 for lisinopril was about two times higher than the ion of m/z 245; however, the former fragment ion was noted to be a little lower than the latter for RSS isomer at all collision energies. In the CID mass spectra of the [M + Li](+) ion, the abundance of the rearrangement ion of m/z 315 for the RSS isomer was about three times higher than that for lisinopril. Furthermore, the difference was supported by the results of energy-resolved mass spectrometry (ERMS) in the test range of collision energies. Similar differences were also observed between the CID mass spectra of lisinopril and RSS isomer methylester, which indicated that the RSS isomer could be rapidly characterized by the CID mass spectra of both the protonated and lithium adduct ion. Elemental compositions of all the ions were confirmed by Fourier Transform ion cyclotron resonance ESI mass spectrometry (FT-ICR-ESI/MS). ...Continue Reading

References

Mar 1, 1985·Analytical Chemistry·C M WhitehouseJ B Fenn
Jan 15, 1988·Biomedical & Environmental Mass Spectrometry·D Renner, G Spiteller
Jun 14, 2000·Drugs·K Simpson, B Jarvis
Feb 24, 2001·Mass Spectrometry Reviews·C Cheng, M L Gross
Sep 1, 2004·Journal of the American Society for Mass Spectrometry·David J Burinsky, Scott L Sides
May 26, 2006·European Journal of Mass Spectrometry·Saifeng PeiYuanjiang Pan
Feb 28, 2007·American Journal of Hypertension·David J EvesonJohn F Potter
Jun 5, 2007·Journal of the American Society for Mass Spectrometry·Richard D HiserodtCynthia J Mussinan
Oct 25, 2008·Journal of the American Society for Mass Spectrometry·Anna R M HyyryläinenPirjo Vainiotalo

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