PMID: 5259765Jul 1, 1969Paper

Differentiation of mammalian somatic cells: DNA and hemoglobin synthesis in fetal mouse yolk sac erythroid cells

Proceedings of the National Academy of Sciences of the United States of America
A De la ChapelleP A Marks

Abstract

The relationship between the synthesis and replication of DNA and the capacity to synthesize specialized protein on a stable messenger RNA has been examined in yolk sac erythroid cells differentiating in vivo in fetal mice. Evidence is presented that by day 11 of gestation, at least 98 per cent of yolk sac erythroid cells are synthesizing hemoglobin. These cells are shown to incorporate (3)H-thymidine and to replicate, with more than twofold increase in cell number between days 10 and 11. Division of these cells continues through day 13. Hemoglobin formation in these cells is resistant to actinomycin D from day 10. During this period, ribosomal content per cell decreases by more than a factor of 2. These data indicate that in yolk sac erythroid cells, hemoglobin formation proceeds independent of continued RNA formation in cells capable of DNA synthesis and replication.

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Citations

May 1, 1971·Developmental Biology·A ShainbergD Yaffe
Oct 1, 1972·Cell Differentiation·A FantoniM Lunadei
Aug 10, 2001·Experimental Hematology·J Palis, M C Yoder
Nov 1, 1971·The Journal of Cell Biology·H K Hagopian, V M Ingram
Jun 1, 1982·The Journal of Cell Biology·A H Sarris, G E Palade
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May 9, 2012·Molecular and Cellular Biology·Christopher J PangMarie Trudel
Nov 3, 2005·Blood·Paul D KingsleyJames Palis
Jan 15, 2014·Stem Cells and Development·Yang LinMomoko Yoshimoto
May 13, 1971·Biochimica Et Biophysica Acta·A Fantoni, S Bordin
Sep 30, 1971·Biochimica Et Biophysica Acta·R K Selander, A De la Chapelle
Apr 26, 1972·Biochimica Et Biophysica Acta·A FantoniL V Pozzi
Feb 13, 2016·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Satoshi KawamuraAlan G Fantel
Aug 6, 2013·Genesis : the Journal of Genetics and Development·Andrei M VacaruMargaret H Baron
Jan 7, 2014·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Lorraine M PosobiecTacey E K White
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Feb 20, 2008·Current Topics in Developmental Biology·Deepa Manwani, James J Bieker
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Dec 14, 1971·Journal of Molecular Biology·M TeradaP A Marks
Mar 3, 1972·Science·P A Marks, R A Rifkind

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