Differentiation of multiple sclerosis from other inflammatory disorders and cerebrovascular disease: value of spinal MR imaging

Radiology
Joost C J BotJonas A Castelijns

Abstract

To determine the value of magnetic resonance (MR) imaging in the spinal cord to differentiate multiple sclerosis (MS) from other inflammatory disorders and cerebrovascular diseases (together, other neurologic disease [OND]). The study population included 66 patients with OND and 25 patients with MS, who were matched for age, sex, and symptom duration or severity. Brain MR imaging included gadolinium-enhanced T1-weighted and dual-echo T2-weighted spin-echo sequences to assess the number, size, and appearance of lesions, contrast enhancement, and compatibility with diagnostic criteria for MS. Spinal cord MR imaging included cardiac-triggered gadolinium-enhanced sagittal T1-weighted spin-echo and dual-echo T2-weighted sequences to assess the general appearance (normal, focal lesion, diffuse abnormality) and number or size of focal lesions. Images obtained in MS and OND patients were compared. Specificity, sensitivity, accuracy, and positive and negative predictive values with MR images were calculated. Brain images were abnormal in all MS patients and in 65% of OND patients. Abnormal cord images were found in 92% of MS and 6% of OND patients. The combination of brain and spinal cord images increased accuracy of diagnosis compared ...Continue Reading

References

May 1, 1975·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·T E FeasbyJ C Kaufmann
Sep 1, 1992·Neurochirurgia·I NishiuraT Koyama
Nov 1, 1992·Annals of Neurology·S WiebeJ H Noseworthy
Aug 1, 1992·British Journal of Rheumatology·C P Simeon-AznarJ A Bosch-Gil
Apr 1, 1989·Journal of Neurology, Neurosurgery, and Psychiatry·L S Honig, W A Sheremata
Sep 1, 1986·AJR. American Journal of Roentgenology·M K EdwardsJ C Stevens
Sep 1, 1987·Neurology·J M Keppel HesselinkJ C Verwey
Sep 1, 1987·Neurology·M A Solomon
Feb 15, 1987·American Journal of Ophthalmology·E Bloch-Michel, R B Nussenblatt
Feb 1, 1985·AJR. American Journal of Roentgenology·K R MaravillaR L Nunnally
Mar 1, 1983·Annals of Neurology·C M PoserW W Tourtellotte
Nov 1, 1982·Arthritis and Rheumatism·E M TanR J Winchester
Nov 1, 1994·Neuroradiology·J Rieger, N Hosten
Jan 1, 1996·Arteriosclerosis, Thrombosis, and Vascular Biology·M van den BergJ A Rauwerda
Jun 11, 1997·JAMA : the Journal of the American Medical Association·I M GrahamG Andria
May 21, 1998·Neuroradiology·M MascalchiG Arnetoli
Jul 23, 1999·Acta Neurologica Scandinavica·H KolleggerR Mallek
Sep 1, 1999·Seminars in Arthritis and Rheumatism·R K Niemelä, M Hakala
Jul 6, 2000·European Radiology·D PickuthS H Heywang-Köbrunner
Aug 10, 2000·Journal of the Neurological Sciences·M RovarisM Filippi
Aug 10, 2000·Journal of the Neurological Sciences·Y ManabeK Abe
May 31, 2001·Circulation·L El-KhairyUNKNOWN European Concerted Action Project
Jan 25, 2002·Multiple Sclerosis : Clinical and Laboratory Research·M TintoréX Montalban

❮ Previous
Next ❯

Citations

Aug 17, 2006·Der Nervenarzt·H WiendlH-P Hartung
Jul 20, 2004·Neuroradiology·Ayşe Tuba Karagülle KendiSerdar Tellioğlu
Mar 12, 2009·Neuroradiology·Mike P Wattjes, Frederik Barkhof
May 17, 2005·Physical Medicine and Rehabilitation Clinics of North America·James Bowen
Aug 28, 2003·Lancet Neurology·Geert LycklamaFrederik Barkhof
Aug 26, 2006·Nature Clinical Practice. Neurology·Jessica M NielsenChris H Polman
Apr 7, 2007·Topics in Magnetic Resonance Imaging : TMRI·John R Hesselink
Jun 23, 2009·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·N ChaussonP Cabre
Apr 29, 2006·BMJ : British Medical Journal·David H Miller, UNKNOWN Steering Committee of MAGNIMS
Mar 21, 2007·Journal of Neurology, Neurosurgery, and Psychiatry·Beatrice BenedettiMassimo Filippi
May 3, 2011·The Journal of Spinal Cord Medicine·Matthew L WhiteKathleen Healey
Mar 7, 2014·PloS One·Darin T OkudaUNKNOWN Club Francophone de la Sclérose en Plaques (CFSEP)
Dec 19, 2009·AJNR. American Journal of Neuroradiology·K-O LövbladM Filippi
Feb 13, 2014·Clinical Neuroradiology·S WeidauerE Hattingen
Mar 22, 2007·Radiographics : a Review Publication of the Radiological Society of North America, Inc·James G SmirniotopoulosJason W Schroeder
Sep 18, 2007·Expert Review of Neurotherapeutics·L J EdwardsC S Constantinescu
Aug 25, 2016·Disability and Rehabilitation·JongHun SungJacob J Sosnoff
Oct 24, 2012·Magnetic Resonance Imaging Clinics of North America·Marco EssigJuan E Gutierrez
May 3, 2012·Neuroimaging Clinics of North America·Iris D KilsdonkMike P Wattjes
Nov 3, 2010·European Journal of Radiology·Cristina Philpott, Peter Brotchie
Apr 27, 2010·Clinical Neurology and Neurosurgery·Miroslav MayerNada Cikes
Oct 6, 2009·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Wei QiuAllan G Kermode
Dec 10, 2008·Neuroimaging Clinics of North America·Joseph C J Bot, Frederik Barkhof
Dec 11, 2008·Neuroimaging Clinics of North America·Anthony Traboulsee, David K B Li
Oct 22, 2005·Annals of Neurology·Jessica M NielsenChris H Polman
Nov 12, 2005·Annals of Neurology·Chris H PolmanJerry S Wolinsky
Apr 12, 2007·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Federica Agosta, Massimo Filippi
Oct 13, 2009·Internal Medicine Journal·C ShawH Butzkueven
Jan 22, 2005·Neurologic Clinics·Anthony TraboulseeDavid K B Li
Jul 23, 2015·Clinical Neuroradiology·M P WattjesM Stangel
Dec 31, 2014·Journal of Neurology·Katherine A BuzzardTodd A Hardy
May 27, 2015·Nature Reviews. Neurology·Hugh KearneyOlga Ciccarelli
Mar 10, 2015·Lancet Neurology·Achim GassUNKNOWN MAGNIMS Study Group
Mar 24, 2012·Lancet Neurology·Massimo FilippiUNKNOWN Attendees of the Correlation between Pathological MRI findings in MS workshop

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.