Differentiation of Nonarteritic Anterior Ischemic Optic Neuropathy from Normal Tension Glaucoma by Comparison of the Lamina Cribrosa

Investigative Ophthalmology & Visual Science
Jeong-Ah KimJeong-Min Hwang

Abstract

To compare lamina cribrosa (LC) morphology between eyes with nonarteritic anterior ischemic optic neuropathy (NAION) and eyes with normal tension glaucoma (NTG) in the Korean population. This retrospective study included 48 eyes with NAION, 48 eyes with NTG, and 48 healthy control eyes matched by age, intraocular pressure, axial length, and optic disc area. Eyes with NAION and NTG were also matched by retinal nerve fiber layer (RNFL) thickness in the affected sector. Optic nerve heads were scanned using enhanced depth imaging spectral-domain optical coherence tomography. LC depth (LCD) and the LC curvature index (LCCI) were measured at seven locations spaced equidistantly across the vertical optic disc diameter. LCD and the LCCI were compared in the three groups. RNFL thicknesses of the matched affected sectors did not differ between the NAION and NTG groups (P = 0.347). LCD and the LCCI were significantly larger in the NTG group than in the NAION and healthy control groups at all seven planes (P < 0.001 each), but were comparable in the NAION and healthy control groups. The LCCI was larger in the affected than in the unaffected sector of NTG eyes (P = 0.010) but did not differ in NAION eyes (P = 1.000). LCD did not differ betw...Continue Reading

Software Mentioned

R
Heidelberg Eye Explorer
Amira
ImageJ
SPSS Statistics

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