PMID: 7011414Jan 26, 1981Paper

Differentiation of ob 17 preadipocytes to adipocytes. Triggering effects of clofenapate and indomethacin

Biochimica Et Biophysica Acta
P VerrandoG Ailhaud

Abstract

Conversion of ob 17 preadipocytes to mature adipose cells is accelerated by addition of clofenapate or of indomethacin, in either the absence or presence of insulin. General stimulation of triacylglycerol-pathway enzymes is observed, as well as dramatic increase in endogenous fatty-acid synthesis. This increase is a function of drug concentration and exposure time. In contrast to indomethacin, the continuous presence of clofenapate after the cells reached confluence was required to observe the effects on adipose conversion. Growth of ob 17 fibroblasts in the presence of 5-bromo-2'-deoxyuridine normally prevents their differentiation to adipose cells. Addition of either clofenapate or indomethacin to these cells at confluence overrides this block. The effects of hypolipidemic drugs such as clofenapate observed on a long-term basis in vitro are consistent with the results of studies on adipose tissue in vivo.

References

Dec 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·T R Russell, R Ho
Feb 20, 1975·Biochimica Et Biophysica Acta·M D GreenspanR Mackow
Jan 1, 1973·Annual Review of Biochemistry·W J RutterP W Morris
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Jan 1, 1980·Biochimie·P VerrandoG Ailhaud

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Citations

Apr 1, 1990·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·R BorojevicH S Dutra
Mar 1, 1996·The Proceedings of the Nutrition Society·G AilhaudP A Grimaldi
Feb 12, 1981·Biochemical and Biophysical Research Communications·R Négrel, G Ailhaud
Sep 1, 2004·Biochemical and Biophysical Research Communications·Yukihiko SugimotoAtsushi Ichikawa
Feb 1, 1995·Prostaglandins, Leukotrienes, and Essential Fatty Acids·G AilhaudP A Grimaldi
Jul 1, 1982·Journal of Cellular Physiology·H A KodamaS Kasai
Mar 1, 1982·Analytical Biochemistry·G Serrero, J C Khoo
Sep 1, 2004·Biochemical and Biophysical Research Communications·Hiroaki TsuboiAtsushi Ichikawa
Mar 24, 2018·The Journal of Pharmacology and Experimental Therapeutics·Lei HaoShu Wang
Mar 30, 2018·International Journal of Endocrinology·Sofia DiasLaura Ribeiro
Mar 9, 1987·Life Sciences·R BrandesJ Bar-Tana
Jun 27, 1986·Biochimica Et Biophysica Acta·R BrandesJ Bar-Tana
Oct 30, 1992·Biochimica Et Biophysica Acta·R M GuaragnaR Borojevic
Nov 1, 1992·Prostaglandins, Leukotrienes, and Essential Fatty Acids·B Richelsen

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