Differentiation of Parkinsonism-Predominant Multiple System Atrophy from Idiopathic Parkinson Disease Using 3T Susceptibility-Weighted MR Imaging, Focusing on Putaminal Change and Lesion Asymmetry.

AJNR. American Journal of Neuroradiology
I HwangJ-H Kim

Abstract

Asymmetric presentation of clinical feature in parkinsonism is common, but correlatable radiologic feature is not clearly defined. Our aim was to evaluate 3T susceptibility-weighted imaging findings for differentiating parkinsonism-predominant multiple system atrophy from idiopathic Parkinson disease, focusing on putaminal changes and lesion asymmetry. This retrospective cohort study included 27 patients with parkinsonism-predominant multiple system atrophy and 50 patients with idiopathic Parkinson disease diagnosed clinically. Twenty-seven age-matched subjects without evidence of movement disorders who underwent SWI were included as the control group. A consensus was reached by 2 radiologists who visually assessed SWI for the presence of putaminal atrophy and marked signal hypointensity on each side of the posterolateral putamen. We also quantitatively measured putaminal width and phase-shift values. The mean disease duration was 4.7 years for the patients with parkinsonism-predominant multiple system atrophy and 7.8 years for the patients with idiopathic Parkinson disease. In the patients with parkinsonism-predominant multiple system atrophy, putaminal atrophy was frequently observed (14/27, 51.9%) and was most commonly found...Continue Reading

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Citations

Oct 25, 2016·Parkinson's Disease·Giovanni RizzoGiancarlo Logroscino
Oct 7, 2017·Journal of Alzheimer's Disease : JAD·Kurt A Jellinger
Mar 25, 2018·Acta Neurologica Scandinavica·L-L BuJ Wang
Oct 13, 2017·Expert Review of Neurotherapeutics·Kurt A Jellinger
Apr 28, 2018·Journal of Neurology·Ming LiWei Yang
Jan 30, 2018·Journal of Alzheimer's Disease : JAD·Christine KaindlstorferGregor K Wenning
Nov 23, 2017·Frontiers in Molecular Neuroscience·Ahmad R ArshadNor Azian Abdul Murad
Jul 28, 2016·Movement Disorders Clinical Practice·Han-Joon KimVictor S C Fung
Apr 16, 2018·Cell and Tissue Research·P RiedererR Krüger

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