PMID: 9525669Apr 3, 1998Paper

Differentiation of promonocytic U937 subclones into macrophagelike phenotypes regulates a cellular factor(s) which modulates fusion/entry of macrophagetropic human immunodeficiency virus type 1

Journal of Virology
H MoriuchiA S Fauci

Abstract

Monocytes/macrophages (M/M) and CD4+ T cells are two important targets of human immunodeficiency virus (HIV) infection. Different strains of HIV-1 vary markedly in their abilities to infect cells belonging to the M/M lineage. Macrophagetropic (M-tropic) HIV-1 strains replicate well in primary lymphocytes as well as in primary macrophages; however, they generally infect T-cell lines poorly, if at all. Although promonocytic cell lines such as U937 have been used as in vitro models of HIV-1 infection of M/M, these cell lines are susceptible to certain T-cell-tropic (T-tropic) HIV-1 strains but are resistant to M-tropic HIV-1. In this study, we demonstrate that (i) certain U937 clones ("plus" clones), which are susceptible only to T-tropic HIV-1, become highly susceptible to M-tropic HIV-1 upon differentiation with retinoic acid (RA); (ii) other U937 clones ("minus" clones), which are resistant to both T- and M-tropic HIV-1, remain resistant to both viruses; and (iii) RA treatment induces expression of CCR5, a fusion/entry cofactor for M-tropic HIV-1 in both types of U937 clones, and yet enhances the fusogenicity of the plus clones, but not the minus clones, with M-tropic Env's. These results indicate that the major restriction of ...Continue Reading

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Citations

Feb 7, 2001·Journal of the National Cancer Institute. Monographs·D T ScaddenT Cheng
Aug 27, 2010·The American Journal of Clinical Nutrition·Eduardo VillamorWafaie W Fawzi
Dec 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Cynthia L BristowRoland R Arnold
Feb 13, 2002·AIDS Research and Human Retroviruses·Krystyna Konopka, Nejat Düzgüneş
Dec 11, 2020·Animals : an Open Access Journal From MDPI·Kornravee PhotichaiKidsadagon Pringproa
Jul 27, 2001·Biochemical and Biophysical Research Communications·M T ChâteauO Coux

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