Differentiation of reactive and tumor metastatic lymph nodes with diffusion-weighted and SPIO-enhanced MRI.

Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging
Fan ZhangXiaoyuan Chen

Abstract

Determination of lymphatic metastasis is of great importance for both treatment planning and patient prognosis. We aim to distinguish tumor metastatic lymph nodes (TLNs) and reactive lymph nodes (RLNs) with diffusion-weighted and superparamagnetic iron oxide (SPIO)-enhanced magnetic resonance imaging (MRI). Ipsilateral popliteal lymph node metastasis or lymphadenitis model was established by hock injection of either luciferase-expressing 4T1 murine breast cancer cells or complete Freund's adjuvant in male BALB/c mice. At different time points after inoculation, bioluminescence imaging and T(2)-weighted, diffusion-weighted, and SPIO-enhanced MRI were performed. Imaging findings were confirmed by histopathological staining. Size enlargement was observed in both TLNs and RLNs. At day 28, TLNs showed strong bioluminescence signal and bigger size than RLNs (p < 0.01). At early stages up to day 21, both TLNs and RLNs appeared homogeneous on diffusion-weighted imaging. At day 28, TLNs showed heterogeneous apparent diffusion coefficient (ADC) map with significantly higher average ADC value of 0.41 ± 0.03 × 10(-3)mm(2)/s than that of RLNs (0.34 ± 0.02 × 10(-3)mm(2)/s; p < 0.05). On SPIO-enhanced MRI, both TLNs and RLNs showed distinct T...Continue Reading

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Citations

Oct 11, 2015·Biotechnology Advances·Anuradha SubramanianSwaminathan Sethuraman
Dec 24, 2014·Proceedings of the National Academy of Sciences of the United States of America·Yu WangXiaoyuan Chen
Jan 6, 2016·Molecular Therapy. Methods & Clinical Development·Drew R DeBayChris V Bowen
Jun 20, 2018·Nanoscale·Elisabetta AvitabileLucia Gemma Delogu
Jan 5, 2019·Asia-Pacific Journal of Clinical Oncology·Ying ZhuJinming Yu
Jan 1, 2014·Physics in Medicine and Biology·Louisa BokachevaJason A Koutcher
Aug 6, 2019·Abdominal Radiology·Hamed KordbachehMukesh G Harisinghani
Jun 12, 2020·Nature Reviews. Materials·Alex SchudelSusan N Thomas

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